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LC3相关的内吞作用以及Rubicon和自噬相关蛋白16L1的功能

LC3-associated endocytosis and the functions of Rubicon and ATG16L1.

作者信息

Magné Joëlle, Green Douglas R

机构信息

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

出版信息

Sci Adv. 2022 Oct 28;8(43):eabo5600. doi: 10.1126/sciadv.abo5600. Epub 2022 Oct 26.

DOI:10.1126/sciadv.abo5600
PMID:36288306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9604520/
Abstract

LC3-associated endocytosis (LANDO) is a noncanonical function of the autophagy machinery, in which LC3 (microtubule-associated protein light chain) is conjugated to rab5-positive endosomes, using a portion of the canonical autophagy pathway. LANDO was initially discovered in a murine model of Alzheimer's disease as a critical regulator of amyloid-β receptor recycling in microglial cells, playing a protective role against neuronal loss and memory impairment. Recent evidence suggests an emerging role of LANDO in cytokine receptor signaling and innate immunity. Here, we discuss the regulation of two crucial effectors of LANDO, Rubicon and ATG16L1, and their impact on endocytosis, autophagy, and phagocytosis.

摘要

LC3相关内吞作用（LANDO）是自噬机制的一种非经典功能，其中LC3（微管相关蛋白轻链）利用部分经典自噬途径与rab5阳性内体结合。LANDO最初在阿尔茨海默病的小鼠模型中被发现，是小胶质细胞中淀粉样β受体循环的关键调节因子，对神经元丢失和记忆损伤起保护作用。最近的证据表明LANDO在细胞因子受体信号传导和先天免疫中发挥着新出现的作用。在这里，我们讨论LANDO的两个关键效应器Rubicon和ATG16L1的调节及其对内吞作用、自噬和吞噬作用的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb4a/9604520/25318dc3ff80/sciadv.abo5600-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb4a/9604520/1c271a68a0f6/sciadv.abo5600-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb4a/9604520/6a4a5241f105/sciadv.abo5600-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb4a/9604520/6ab03ba2b415/sciadv.abo5600-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb4a/9604520/25318dc3ff80/sciadv.abo5600-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb4a/9604520/1c271a68a0f6/sciadv.abo5600-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb4a/9604520/6a4a5241f105/sciadv.abo5600-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb4a/9604520/6ab03ba2b415/sciadv.abo5600-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb4a/9604520/25318dc3ff80/sciadv.abo5600-f4.jpg

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