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圆锥角膜基质内同种异体角膜移植术后视力质量的变化(临床观察)

[Changes in the quality of vision after intrastromal allokeratoplasty for keratoconus (clinical observation)].

作者信息

Sheludchenko V M, Yusef Yu N, Osipyan G A, Dzhalili R A

机构信息

Research Institute of Eye Diseases, Moscow, Russia.

出版信息

Vestn Oftalmol. 2022;138(5):87-93. doi: 10.17116/oftalma202213805187.

DOI:10.17116/oftalma202213805187
PMID:36288422
Abstract

Scleral lenses, corneal collagen crosslinking, corneal implants and deep anterior keratoplasty are used to correct deforming changes in the cornea at advanced stages of keratoconus, which improves the quality of vision (QoV). The article presents an analysis of changes in QoV in a 30-year-old patient with stage III keratoconus who underwent intracorneal implantation of an allograft with a width of 2.75 mm and thickness of 300 µm at a depth of 370 µm. The following parameters were measured before and 6 months after the procedure: uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), VA with glare, higher order aberrations (HOA), thickness of the lipid layer of the tear film, spatial contrast sensitivity, visual productivity. Observation results show that the K index decreased from 55.9 D to 48.0 D, K - from 39.8 D to 39.4 D, UCVA increased from 0.1 to 0.8 and BCVA - from 0.35 to 0.8. Thickness of the lipid layer of the tear film remained the same. The glare effect with different degrees of brightness did not affect visual acuity. Spatial contrast sensitivity in photopic conditions at medium frequencies increased from 19 to 37 dB, at high frequencies from - 0.5 to 22.5 dB, in mesopic conditions at medium frequencies from 11 to 28 dB, at high frequencies from - 0.5 to 12 dB. The «coma» and «spherical» aberrations decreased by 2 and 3 times, respectively, while «trefoil» increased by 3 times. Visual productivity increased by 36.8%. It may be concluded that the use of a wide intrastromal allograft in keratoconus improves the patient's visual quality and visual productivity. At the same time, the «vignetting» effect from the graft side is negligible in photopic conditions and is significant in mesopic conditions.

摘要

巩膜镜、角膜胶原交联、角膜植入物和深前层角膜移植术用于矫正圆锥角膜晚期角膜的变形变化,从而提高视力质量(QoV)。本文分析了一名30岁III期圆锥角膜患者的视力质量变化,该患者在角膜370µm深度处植入了宽度为2.75mm、厚度为300µm的同种异体角膜移植片。在手术前和术后6个月测量了以下参数:未矫正视力(UCVA)、最佳矫正视力(BCVA)、眩光下视力、高阶像差(HOA)、泪膜脂质层厚度、空间对比敏感度、视觉效能。观察结果显示,角膜曲率计读数从55.9D降至48.0D,K值从39.8D降至39.4D,UCVA从0.1提高到0.8,BCVA从0.35提高到0.8。泪膜脂质层厚度保持不变。不同亮度程度的眩光效应不影响视力。明视条件下中频的空间对比敏感度从19dB提高到37dB,高频从 - 0.5dB提高到22.5dB,中间视觉条件下中频从11dB提高到28dB,高频从 - 0.5dB提高到12dB。“彗差”和“球差”分别降低了2倍和3倍,而“三叶草像差”增加了3倍。视觉效能提高了36.8%。可以得出结论,在圆锥角膜中使用宽基质内同种异体移植片可改善患者的视觉质量和视觉效能。同时,在明视条件下,移植片一侧的“渐晕”效应可忽略不计,而在中间视觉条件下则较为显著。

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