脉冲射频治疗眶上神经痛的长期疗效：一项回顾性多中心研究。

Long-term Outcomes of Pulsed Radiofrequency for Supraorbital Neuralgia: A Retrospective Multicentric Study.

机构信息

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Imaging Department, Beijing Puhua International Hospital, Beijing, China.

出版信息

Pain Physician. 2022 Oct;25(7):E1121-E1128.

PMID:36288599

Abstract

BACKGROUND

Pulsed radiofrequency (PRF) is a percutaneous, micro-invasive, and micro-destructive neuromodulation technology. It has been reported to be useful in the treatment of supraorbital neuralgia (SN). However, the long-term effectiveness and safety of this technique in SN has not been reported yet.

OBJECTIVES

To investigate the outcomes of PRF on supraorbital neuralgia (SN) in multi-centers and a long-term perspective.

STUDY DESIGN

Retrospective case series.

METHODS

Patients who underwent PRF for SN at 4 hospitals in Beijing between Jan 2007 and Jan 2021 were identified and reviewed for inclusion. Their demographic data and baseline conditions were statistically described, and their conditions of pain control were analyzed using Kaplan-Meier survival analyses. A survival curve was plotted, the cumulative proportion of pain-free at specific time points was determined, and the median pain-free time was estimated. Complications related to PRF treatment were summarized. The risk factors for initial pain control and pain-free survival were analyzed using logistic regression and Cox regression.

RESULTS

A total of 116 patients were included; 91 (78.4%) patients got initial pain control with just one attempt of PRF. The maximum length of follow-up was 127 months, with a median of 18 months. During follow-up, 29 (31.9%) patients suffered from pain recurrence, and 11 (12.1%) were lost. The cumulative pain-free survival at 6 months, 1 year, 2 years, 3 years, 5 years, 8 years, and 10 years were estimated as 70%, 64%, 59%, 55%, 44%, 37%, and 37%, respectively. The median pain-free time was 52 months. No severe complications were observed or reported. Duration of disease could significantly influence initial pain control, while no risk factors for pain-free survival were recognized.

LIMITATIONS

A retrospective study setting without a control group.

CONCLUSION

The performance of PRF for the treatment of SN was confirmed to be favorable in a multicentric, relatively large scale, and long-term perspective.

摘要

背景

脉冲射频（PRF）是一种经皮、微创、微破坏性的神经调节技术。据报道，它对眶上神经痛（SN）的治疗有效。然而，这种技术治疗 SN 的长期效果和安全性尚未有报道。

目的

在多中心和长期角度探讨 PRF 治疗 SN 的结果。

研究设计

回顾性病例系列。

方法

在北京的 4 家医院，从 2007 年 1 月至 2021 年 1 月期间，对接受 PRF 治疗 SN 的患者进行了识别和回顾性纳入。对患者的人口统计学数据和基线情况进行了统计描述，并采用 Kaplan-Meier 生存分析对其疼痛控制情况进行了分析。绘制生存曲线，确定特定时间点无疼痛的累积比例，并估计无疼痛时间的中位数。总结与 PRF 治疗相关的并发症。采用 logistic 回归和 Cox 回归分析初始疼痛控制和无疼痛生存的风险因素。

结果

共纳入 116 例患者；91 例（78.4%）患者仅接受一次 PRF 治疗即获得初始疼痛缓解。最长随访时间为 127 个月，中位数为 18 个月。随访期间，29 例（31.9%）患者出现疼痛复发，11 例（12.1%）患者失访。6 个月、1 年、2 年、3 年、5 年、8 年和 10 年的累积无疼痛生存率估计值分别为 70%、64%、59%、55%、44%、37%和 37%。无疼痛时间的中位数为 52 个月。未观察到或报告严重并发症。疾病持续时间可显著影响初始疼痛控制，而无疼痛生存的风险因素未被识别。