Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (Hospital.C.T.), Chengdu, Sichuan 610041, China.
Endocr J. 2023 Feb 28;70(2):185-196. doi: 10.1507/endocrj.EJ22-0419. Epub 2022 Oct 26.
Iron overload can lead to chronic complications, serious organ dysfunction or death in the body. Under hypoxic conditions, the body needs more iron to produce red blood cells to adapt to the hypoxic environment. The prevalence of iron overload in the Tibetan population is higher than that in the Han population. To explore the molecular mechanism of iron-overload in the Tibetan population, this study investigated the transcriptome of the Tibetan iron overload population to obtain differentially expressed genes (DEGs) between the iron-overloaded population and the normal iron population. Functional enrichment analysis identified key related pathways, gene modules and coexpression networks under iron-overload conditions, and the 4 genes screened out have the potential to become target genes for studying the development of iron overload. A total of 28 pathways were screened to be closely related to the occurrence and development of iron overload, showing that iron overload is extremely related to erythrocyte homeostasis, cell cycle, oxidative phosphorylation, immunity, and transcriptional repression.
铁过载可导致体内慢性并发症、严重器官功能障碍甚至死亡。在缺氧条件下，机体需要更多的铁来生成红细胞以适应缺氧环境。藏族人群铁过载的患病率高于汉族人群。为了探索藏族人群铁过载的分子机制，本研究对藏族铁过载人群的转录组进行了研究，以获得铁过载人群和正常铁人群之间的差异表达基因（DEGs）。功能富集分析鉴定了铁过载条件下关键相关途径、基因模块和共表达网络，筛选出的 4 个基因具有成为研究铁过载发生发展的潜在靶基因的潜力。共筛选出 28 条与铁过载发生和发展密切相关的途径，表明铁过载与红细胞内稳态、细胞周期、氧化磷酸化、免疫和转录抑制等过程密切相关。
