头孢曲松在小鼠中的雾化吸入给药：生成过程、药代动力学和治疗结果。
Aerosol Inhalation Delivery of Ceftriaxone in Mice: Generation Procedure, Pharmacokinetics, and Therapeutic Outcome.
作者信息
Valiulin Sergey V, Onischuk Andrei A, Baklanov Anatoly M, An'kov Sergey V, Dubtsov Sergey N, Alekseev Alexander A, Shkil Nikolay N, Nefedova Ekaterina V, Plokhotnichenko Maria E, Tolstikova Tatyana G, Dolgov Arseniy M, Dultseva Galina G
机构信息
Voevodsky Institute of Chemical Kinetics and Combustion SB RAS, 3 Institutskaya Str., 630090 Novosibirsk, Russia.
Vorozhtsov Institute of Organic Chemistry SB RAS, 9 Lavrentyev Ave., 630090 Novosibirsk, Russia.
出版信息
Antibiotics (Basel). 2022 Sep 25;11(10):1305. doi: 10.3390/antibiotics11101305.
Aerosol inhalation delivery of ceftriaxone in mice was investigated. An ultrasonic nebulizer within the ranges of mean particle diameter 0.5-1.5 μm and mass concentration 0.01-0.6 μg/cm was used in inhalation experiments. Pharmacokinetic measurements were carried out using a nose-only chamber. Ceftriaxone concentration in blood serum and its mass in the lungs of mice were measured as a function of time using high-performance liquid chromatography. The body-delivered dose was within the range 3-5 mg/kg. The antibacterial effect of aerosolized ceftriaxone was investigated for mice infected with 82 and ATCC 25 953. The survival rate for infected mice after the treatment with ceftriaxone aerosol revealed the high antibacterial efficiency of this kind of treatment.
研究了头孢曲松在小鼠中的雾化吸入给药。吸入实验中使用了平均粒径在0.5 - 1.5μm范围内、质量浓度在0.01 - 0.6μg/cm的超声雾化器。使用仅鼻暴露舱进行药代动力学测量。采用高效液相色谱法测定血清中头孢曲松浓度及其在小鼠肺中的质量随时间的变化。经身体给予的剂量在3 - 5mg/kg范围内。研究了雾化头孢曲松对感染82和ATCC 25953的小鼠的抗菌效果。用头孢曲松气雾剂治疗后，感染小鼠的存活率显示出这种治疗方法具有很高的抗菌效率。
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