菌血症患者人工关节感染的患病率及相关因素：一项7年回顾性研究
Prevalence and Factors Associated with Prosthetic Joint Infections in Patients with Bacteraemia: A 7-Year Retrospective Study.
作者信息
Papadimitriou-Olivgeris Matthaios, Senn Laurence, Bertelli Claire, Grandbastien Bruno, Steinmetz Sylvain, Boillat-Blanco Noémie
机构信息
Infectious Diseases Service, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.
Infection Prevention and Control Unit, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.
出版信息
Antibiotics (Basel). 2022 Sep 28;11(10):1323. doi: 10.3390/antibiotics11101323.
Background: Staphylococcus aureus is the main cause of haematogenous prosthetic joint infections (PJI). We aimed to describe the prevalence and factors associated with PJI in patients with documented S. aureus bacteraemia. Methods: Adult patients with S. aureus bacteraemia and presence of prosthetic joint hospitalized in Lausanne University Hospital during a seven-year period (2015−2021) were included. Results: Among 135 patients with S. aureus bacteraemia and prosthetic joints, 38 (28%) had PJI. Multivariate analysis revealed that the presence of PJI was associated with knee arthroplasty (P 0.029; aOR 3.00, 95% CI 1.12−8.05), prior arthroplasty revision (P 0.034; aOR 3.59, 95% CI 1.10−11.74), community-acquired bacteraemia (P 0.005; aOR 4.74, 95% CI 1.61−14.01) and age < 70 years (P 0.007; aOR 9.39, 95% CI 1.84−47.85). Conclusions: PJI was common among patients with documented S. aureus bacteraemia. PJI was associated with characteristics of the prosthesis, such as prior arthroplasty revisions and knee prosthesis.
背景
金黄色葡萄球菌是血源性人工关节感染（PJI）的主要病因。我们旨在描述有金黄色葡萄球菌菌血症记录的患者中PJI的患病率及相关因素。方法：纳入在洛桑大学医院住院的、在七年期间（2015 - 2021年）患有金黄色葡萄球菌菌血症且存在人工关节的成年患者。结果：在135例患有金黄色葡萄球菌菌血症且有假体关节的患者中，38例（28%）发生了PJI。多因素分析显示，PJI的发生与膝关节置换术（P = 0.029；调整后比值比[aOR] 3.00，95%置信区间[CI] 1.12 - 8.05）、既往关节置换翻修术（P = 0.034；aOR 3.59，95% CI 1.10 - 11.74）、社区获得性菌血症（P = 0.005；aOR 4.74，95% CI 1.61 - 14.01）以及年龄<70岁（P = 0.007；aOR 9.39，95% CI 1.84 - 47.85）相关。结论：在有金黄色葡萄球菌菌血症记录的患者中，PJI很常见。PJI与假体的特征相关，如既往关节置换翻修术和膝关节假体。
Zotero 插件