Xia Yudong, Zhai Xiaoying, Qiu Yanning, Lu Xuemei, Jiao Yi
State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Xinjiang Key Laboratory of Molecular Biology for Endemic Diseases, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830011, China.
Antioxidants (Basel). 2022 Oct 20;11(10):2067. doi: 10.3390/antiox11102067.
Obesity and its complications have become serious global health concerns recently and increasing work has been carried out to explicate the underlying mechanism of the disease development. The recognized correlations suggest oxidative stress and inflammation in expanding adipose tissue with excessive fat accumulation play important roles in the pathogenesis of obesity, as well as its associated metabolic syndromes. In adipose tissue, obesity-mediated insulin resistance strongly correlates with increased oxidative stress and inflammation. Nuclear factor erythroid 2-related factor 2 (Nrf2) has been described as a key modulator of antioxidant signaling, which regulates the transcription of various genes coding antioxidant enzymes and cytoprotective proteins. Furthermore, an increasing number of studies have demonstrated that Nrf2 is a pivotal target of obesity and its related metabolic disorders. However, its effects are controversial and even contradictory. This review aims to clarify the complicated interplay among Nrf2, oxidative stress, lipid metabolism, insulin signaling and chronic inflammation in obesity. Elucidating the implications of Nrf2 modulation on obesity would provide novel insights for potential therapeutic approaches in obesity and its comorbidities.
肥胖及其并发症近来已成为严重的全球健康问题，并且人们开展了越来越多的工作来阐释该疾病发展的潜在机制。公认的相关性表明，在脂肪过度积累的扩张脂肪组织中，氧化应激和炎症在肥胖及其相关代谢综合征的发病机制中起重要作用。在脂肪组织中，肥胖介导的胰岛素抵抗与氧化应激和炎症增加密切相关。核因子红细胞2相关因子2（Nrf2）被描述为抗氧化信号的关键调节因子，它调节各种编码抗氧化酶和细胞保护蛋白的基因的转录。此外，越来越多的研究表明，Nrf2是肥胖及其相关代谢紊乱的关键靶点。然而，其作用存在争议甚至相互矛盾。本综述旨在阐明肥胖中Nrf2、氧化应激、脂质代谢、胰岛素信号传导和慢性炎症之间复杂的相互作用。阐明Nrf2调节对肥胖的影响将为肥胖及其合并症的潜在治疗方法提供新的见解。
