Department of Pathology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Curr Oncol. 2022 Sep 21;29(10):6764-6775. doi: 10.3390/curroncol29100532.
Ganglioglioma is a well-circumscribed low-grade glioneuronal tumor with a broad morphological spectrum. Diffuse glioneuronal tumors are used to describe cases with infiltrative growth. Molecular studies of some of these cases are consistent with ganglioglioma. This work aimed to clarify the growth patterns in ganglioglioma. The available slides and clinical and molecular information for 46 patients (50 samples) with a diagnosis of ganglioglioma under the open pediatric brain tumor atlas from the children's brain tumor network database were reviewed to confirm the integrated diagnosis and to evaluate the growth patterns in these cases. Ten samples from nine patients were excluded as no slides were available, the integrated diagnoses were changed in seven cases (nine samples), ten cases (ten samples) were diagnosed as low-grade glial/glioneuronal tumors, and the diagnosis of ganglioglioma was confirmed in seventeen samples from sixteen patients (nine females and seven males; age ranges from eight months-19 years with a mean of 9.9 years). Infiltration is defined as the presence of neoplastic cells among the nonneoplastic parenchyma. The growth pattern was predominantly circumscribed in six cases, predominantly infiltrative in five cases, and combined growth patterns in five cases. This work confirmed the presence of an infiltrative/diffuse variant of ganglioglioma as a significant pattern. The differential diagnosis in these cases was mainly infiltrative glioma, usually -wild type in this population, which may introduce a high-grade glioma in the differential. Awareness of infiltrative ganglioglioma variants should be helpful in this scenario.
神经节神经胶质瘤是一种边界清楚的低级神经胶质神经元肿瘤，具有广泛的形态学谱。弥漫性神经胶质神经元肿瘤用于描述具有浸润性生长的病例。对这些病例中的一些进行的分子研究与神经节神经胶质瘤一致。本研究旨在阐明神经节神经胶质瘤的生长模式。回顾了来自儿童脑瘤网络数据库的儿童脑肿瘤图谱下的 46 名患者（50 个样本）的现有幻灯片以及临床和分子信息，以确认综合诊断，并评估这些病例中的生长模式。由于没有幻灯片，九名患者的十个样本被排除在外，七个病例（九个样本）的综合诊断发生了改变，十个病例（十个样本）被诊断为低级别胶质/神经胶质神经元肿瘤，并且神经节神经胶质瘤的诊断在十六名患者（九名女性和七名男性；年龄从八个月到 19 岁，平均年龄为 9.9 岁）的十七个样本中得到了证实。浸润是指肿瘤细胞存在于非肿瘤实质之间。生长模式在六个病例中主要是局限性的，在五个病例中主要是浸润性的，在五个病例中是混合性生长模式。本研究证实了神经节神经胶质瘤浸润/弥漫性变体的存在是一种重要的模式。在这些病例中，主要的鉴别诊断是浸润性胶质瘤，通常在该人群中为野生型，这可能会在鉴别诊断中引入高级别胶质瘤。浸润性神经节神经胶质瘤变体的认识在这种情况下应该是有帮助的。
