帕金森病患者淡漠的影响因素分析
Analysis of Influencing Factors of Apathy in Patients with Parkinson's Disease.
作者信息
Luo Ruirui, Qi Yumeng, He Jiuqin, Zheng Xiaoqi, Ren Wenhua, Chang Ying
机构信息
Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
School of Statistics, East China Normal University, Shanghai 200050, China.
出版信息
Brain Sci. 2022 Oct 4;12(10):1343. doi: 10.3390/brainsci12101343.
BACKGROUND
Apathy is a common non-motor symptom of Parkinson's disease (PD). The influencing factors of apathy are currently controversial. This study aimed to describe the clinical characteristics of PD-associated apathy and to analyze the associated risk factors.
METHODS
Two hundred patients diagnosed with PD were selected. Included patients were divided into an apathetic group and a non-apathetic group. Demographic and clinical data, motor symptoms, non-motor symptoms and medication use of the two groups were assessed.
RESULTS
The incidence of apathy was 69%. Demographic and clinical data, motor symptoms, non-motor symptoms and medications use were statistically significant.
CONCLUSIONS
PD patients with more severe motor symptoms, cognitive impairment, depression, anxiety, RBD, excessive daytime sleep, fatigue, low education level, long disease course, poor quality of life and lower DA dosage are more prone to apathy. Cognitive function, quality of life, educational level, DA and LEDD are independent risk factors for apathy.
背景
冷漠是帕金森病（PD）常见的非运动症状。目前，冷漠的影响因素存在争议。本研究旨在描述帕金森病相关性冷漠的临床特征，并分析相关危险因素。
方法
选取200例确诊为帕金森病的患者。纳入患者分为冷漠组和非冷漠组。评估两组的人口统计学和临床数据、运动症状、非运动症状及药物使用情况。
结果
冷漠发生率为69%。人口统计学和临床数据、运动症状、非运动症状及药物使用情况差异有统计学意义。
结论
运动症状更严重、存在认知障碍、抑郁、焦虑、快速眼动睡眠行为障碍、日间过度嗜睡、疲劳、教育水平低、病程长、生活质量差及多巴胺剂量较低的帕金森病患者更容易出现冷漠。认知功能、生活质量、教育水平、多巴胺及左旋多巴等效剂量是冷漠的独立危险因素。
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