Ota Takeshi, Mori Jun, Kawabe Yasuhiro, Morimoto Hidechika, Fukuhara Shota, Kodo Kazuki, Sugimoto Satoru, Kosaka Kitaro, Nakajima Hisakazu, Hosoi Hajime
Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Children (Basel). 2022 Sep 20;9(10):1421. doi: 10.3390/children9101421.
Genetic factors play critical roles in the onset and progression of obesity. Brown adipose tissue (BAT) activity is also critical for adiposity. The objective of this study was to evaluate the prevalence and effects of BAT gene polymorphisms in pediatric obesity. This case-control study included 270 non-obese and 86 obese children. All participants underwent genotyping for type 2 deiodinase (DIO2) Thr92Ala (rs225014). The prevalence of the homozygous Ala/Ala allele of the DIO2 gene in the obese group was 15.1% versus 6.3% in the non-obese group, resulting in an odds ratio (OR) of 3.393 ( = 0.003). The results of this study indicate that the homozygous Ala/Ala allele of the DIO2 gene is associated with an increased risk of pediatric obesity and suggest that pediatric obesity might be suitable for assessing the association with gene polymorphisms related to BAT, especially DIO2 Thr92Ala.
遗传因素在肥胖症的发生和发展中起着关键作用。棕色脂肪组织（BAT）的活性对肥胖也至关重要。本研究的目的是评估儿童肥胖中BAT基因多态性的患病率及其影响。这项病例对照研究纳入了270名非肥胖儿童和86名肥胖儿童。所有参与者均接受了2型脱碘酶（DIO2）Thr92Ala（rs225014）的基因分型。肥胖组中DIO2基因纯合Ala/Ala等位基因的患病率为15.1%，而非肥胖组为6.3%，比值比（OR）为3.393（P = 0.003）。本研究结果表明，DIO2基因的纯合Ala/Ala等位基因与儿童肥胖风险增加相关，并提示儿童肥胖可能适合用于评估与BAT相关的基因多态性的关联，尤其是DIO2 Thr92Ala。
