Department of Experimental Biology, The Faculty of Biology and Animal Science, The University of Environmental and Life Sciences, 50-375 Wroclaw, Poland.
Biomolecules. 2022 Oct 20;12(10):1525. doi: 10.3390/biom12101525.
Cyclosporine A (CsA) is a selective and reversible immunosuppressant agent that is widely used as a medication for a wide spectrum of diseases in humans such as graft versus host disease, non-infectious uveitis, rheumatoid arthritis, psoriasis, and atopic dermatitis. Furthermore, the CsA is used to treat keratoconjunctivitis sicca, chronic superficial keratitis, immune-mediated keratitis and equine recurrent uveitis in animals. The selective activity of Cyclosporine A (CsA) was demonstrated to be an immunomodulation characteristic of T-lymphocyte proliferation and inhibits cytokine gene expression. Moreover, the lipophilic characteristics with poor bioavailability and low solubility in water, besides the side effects, force the need to develop new formulations and devices that will provide adequate penetration into the anterior and posterior segments of the eye. This review aims to summarize the effectiveness and safety of cyclosporine A delivery platforms in veterinary ophthalmology.
环孢素 A（CsA）是一种选择性和可逆的免疫抑制剂，广泛用作治疗人类多种疾病的药物，如移植物抗宿主病、非传染性葡萄膜炎、类风湿关节炎、银屑病和特应性皮炎。此外，CsA 还用于治疗动物的干燥性角膜结膜炎、慢性浅层角膜炎、免疫介导性角膜炎和马复发性葡萄膜炎。环孢素 A（CsA）的选择性活性被证明是 T 淋巴细胞增殖的免疫调节特征，并抑制细胞因子基因表达。此外，亲脂性差、生物利用度低、水中溶解度低以及副作用等特点，迫使需要开发新的制剂和设备，以提供足够的穿透前节和后节的眼部。本文综述旨在总结环孢素 A 在兽医眼科中的传递平台的有效性和安全性。
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