伦敦西北部关于治疗相关毒性对老年生殖细胞肿瘤患者临床结局影响的经验
A North-West London Experience of the Impact of Treatment Related Toxicity on Clinical Outcomes of Elderly Patients with Germ Cell Tumors.
作者信息
Sharma Anand, Morrison Laura, Milic Marina, Ghose Aruni, Gogbashian Andrew, Vasdev Nikhil, Agarwal Samita, Pullar Ben, Rustin Gordon
机构信息
Department of Medical Oncology, Mount Vernon Cancer Centre, London HA6 2RN, UK.
Department of Radiology, Mount Vernon Cancer Centre, Paul Strickland Scanner Centre, London HA6 2RN, UK.
出版信息
Cancers (Basel). 2022 Oct 11;14(20):4977. doi: 10.3390/cancers14204977.
Background/Aim: The occurrence of germ cell tumour (GCT) in the elderly is rare, with scarce data available. The aim of this study was to understand the clinical outcomes of patients with GCT in patients aged > 45 years. Materials and Methods: A retrospective study was conducted in a large tertiary cancer centre in north-west London. Between 1 January 2003 and 31 March 2022, 108 cases of GCT in men aged > 45 years were identified and treated at the Mount Vernon Cancer Centre. The median age at diagnosis was 54 years (range = 45−70 years). Results: The 5-year survival rate of all patients was 96%, and the toxicity profile was similar to the younger age group. Conclusion: Older patients with GCT are able to tolerate chemotherapy; however, care must be taken to prevent life-threatening complications using appropriate dose modification.
背景/目的：老年生殖细胞肿瘤（GCT）的发生较为罕见，可用数据稀缺。本研究的目的是了解年龄大于45岁的GCT患者的临床结局。材料与方法：在伦敦西北部的一家大型三级癌症中心进行了一项回顾性研究。2003年1月1日至2022年3月31日期间，在弗农山癌症中心确诊并治疗了108例年龄大于45岁的男性GCT患者。诊断时的中位年龄为54岁（范围 = 45 - 70岁）。结果：所有患者的5年生存率为96%，毒性特征与较年轻年龄组相似。结论：老年GCT患者能够耐受化疗；然而，必须谨慎使用适当的剂量调整来预防危及生命的并发症。
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