Ghazarian Armen A, Rusner Carsten, Trabert Britton, Braunlin Megan, McGlynn Katherine A, Stang Andreas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA; Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Department of Radiology, St. Elisabeth and St. Barbara Hospital, Halle (Saale), Germany.
Cancer Epidemiol. 2018 Aug;55:68-72. doi: 10.1016/j.canep.2018.05.007.
The incidence of testicular cancer in the United States (US) has substantially increased in recent decades. The majority of testicular cancers are germ cell tumors (TGCT), which are the most commonly occurring malignancies among men aged 15-44 years in the US. To date, few studies have focused on testicular cancer among men aged ≥ 50 years. Thus, we sought to examine detailed descriptive features, including incidence rates and age patterns, of tumors that arise in the testes among men aged ≥ 50 years.
Data from forty-one US cancer registries were included for the years 1999-2014. Incidence rates per 100,000 person-years and their 95% confidence intervals (CI) were calculated by race/ethnicity, histology, and age at diagnosis. Estimates of annual percent change (APC) were also calculated.
Age-specific incidence rates of spermatocytic tumors, sex cord stromal tumors and lymphomas rose with age, while age-specific incidence rates of seminomas and nonseminomas declined. Between 1999 and 2014, the incidence of nonseminoma (APC = 3.26, 95% CI: 2.27-4.25) increased more than any other tumor type. The incidence of seminoma (APC: 1.15, 95% CI: 0.59-1.71) also increased, while rates of testicular lymphoma (APC: -0.66, 95% CI: -1.16 to -0.16), spermatocytic tumors (APC: 0.42, 95% CI: -1.42 to 2.29), and sex cord stromal tumors (APC: 0.60, 95% CI: -3.21 to 4.55) remained relatively unchanged.
Given the distinct time-trends and age-specific patterns of testicular cancer in men aged ≥50 years, additional investigation of risk factors for these tumors is warranted.
近几十年来，美国睾丸癌的发病率大幅上升。大多数睾丸癌是生殖细胞肿瘤（TGCT），是美国15 - 44岁男性中最常见的恶性肿瘤。迄今为止，很少有研究关注50岁及以上男性的睾丸癌。因此，我们试图研究50岁及以上男性睾丸肿瘤的详细描述特征，包括发病率和年龄模式。
纳入了1999年至2014年美国41个癌症登记处的数据。按种族/族裔、组织学和诊断时年龄计算每10万人年的发病率及其95%置信区间（CI）。还计算了年度百分比变化（APC）的估计值。
精母细胞瘤、性索间质肿瘤和淋巴瘤的年龄别发病率随年龄增长而上升，而精原细胞瘤和非精原细胞瘤的年龄别发病率下降。1999年至2014年期间，非精原细胞瘤的发病率（APC = 3.26，95% CI：2.27 - 4.25）增长幅度超过其他任何肿瘤类型。精原细胞瘤的发病率（APC：1.15，95% CI：0.59 - 1.71）也有所上升，而睾丸淋巴瘤（APC： - 0.66，95% CI： - 1.16至 - 0.16）、精母细胞瘤（APC：0.42，95% CI： - 1.42至2.29）和性索间质肿瘤（APC：0.60，95% CI： - 3.21至4.55）的发病率相对保持不变。
鉴于50岁及以上男性睾丸癌有明显的时间趋势和年龄别模式，有必要对这些肿瘤的危险因素进行进一步调查。
