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胎盘，早产中新冠病毒感染的关键见证者。

Placenta, the Key Witness of COVID-19 Infection in Premature Births.

作者信息

Bobei Tina-Ioana, Sima Romina-Marina, Gorecki Gabriel-Petre, Poenaru Mircea-Octavian, Olaru Octavian-Gabriel, Bobirca Anca, Cirstoveanu Catalin, Chicea Radu, Topirceanu-Andreoiu Oana-Maria, Ples Liana

机构信息

Department PhD, IOSUD, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.

出版信息

Diagnostics (Basel). 2022 Sep 26;12(10):2323. doi: 10.3390/diagnostics12102323.

DOI:10.3390/diagnostics12102323
PMID:36292012
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9600231/
Abstract

Adverse perinatal outcomes, such as increased risks of pre-eclampsia, miscarriage, premature birth, and stillbirth have been reported in SARS-CoV-2 infection. For a better understanding of COVID-19 complications in pregnancy, histopathological changes in the placenta, which is the interface between mother and foetus, could be the place to look at. The aim of this study was to determine placental histopathological changes and their role in preterm birth in pregnant women with SARS-CoV-2 infection. We performed a prospective, observational study in a COVID-only hospital, which included 39 pregnant women with SARS-CoV-2 infection and preterm birth compared with a control group of 39 women COVID-19 negative with preterm birth and a placental pathology exam available. The microscopic examination of all placentas revealed placental infarction (64.1% vs. 30.8%), decidual arteriopathy (66.7% vs. 23.1%), intervillous thrombi (53.8% vs. 38.5%), perivillous fibrin deposits (59% vs. 46.2%), inflammatory infiltrate (69.2% vs. 46.2%), chorangiosis (17.9% vs. 10.3%), and accelerated maturation of the villi (23.1% vs. 28.2%).

摘要

据报道，感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）会出现不良围产期结局，如子痫前期、流产、早产和死产风险增加。为了更好地了解妊娠期2019冠状病毒病（COVID-19）并发症，胎盘作为母婴之间的界面，其组织病理学变化可能是研究的着眼点。本研究的目的是确定SARS-CoV-2感染孕妇的胎盘组织病理学变化及其在早产中的作用。我们在一家仅收治COVID-19患者的医院进行了一项前瞻性观察性研究，该研究纳入了39例SARS-CoV-2感染且早产的孕妇，并与39例COVID-19阴性且早产且有胎盘病理学检查结果的女性组成的对照组进行比较。所有胎盘的显微镜检查显示胎盘梗死（64.1%对30.8%）、蜕膜动脉病（66.7%对23.1%）、绒毛间隙血栓（53.8%对38.5%）、绒毛周围纤维蛋白沉积（59%对46.2%）、炎性浸润（69.2%对46.2%）、绒毛血管增多（17.9%对10.3%）以及绒毛加速成熟（23.1%对28.2%）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f32/9600231/edb269f6c181/diagnostics-12-02323-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f32/9600231/771a5c5ae327/diagnostics-12-02323-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f32/9600231/df35295e1076/diagnostics-12-02323-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f32/9600231/3755ced738ef/diagnostics-12-02323-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f32/9600231/5a52df4ad0a6/diagnostics-12-02323-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f32/9600231/edb269f6c181/diagnostics-12-02323-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f32/9600231/771a5c5ae327/diagnostics-12-02323-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f32/9600231/df35295e1076/diagnostics-12-02323-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f32/9600231/3755ced738ef/diagnostics-12-02323-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f32/9600231/5a52df4ad0a6/diagnostics-12-02323-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f32/9600231/edb269f6c181/diagnostics-12-02323-g005.jpg

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