超声引导下射频消融治疗多内分泌腺瘤病1型所致原发性甲状旁腺功能亢进——病例报告

Ultrasound-Guided Radiofrequency Ablation for Primary Hyperparathyroidism Induced by Multiple Endocrine Neoplasia 1-A Case Report.

作者信息

Han Zhenping, Li Tingting, Wang Siyi, Gao Li, Hu Ying, Zhao Yu, Yan Jieping

机构信息

Center for Clinical Pharmacy, Department of Pharmacy, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, China.

Department of Pharmacology, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.

出版信息

Diagnostics (Basel). 2022 Oct 20;12(10):2553. doi: 10.3390/diagnostics12102553.

DOI:10.3390/diagnostics12102553

PMID:36292242

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9600646/

Abstract

Multiple endocrine neoplasia type 1 (MEN1) is a syndrome characterized by the occurrence of two or more endocrine gland tumors. Here, we show a case of a 52-year-old man diagnosed with MEN1 through gastrinoma, parathyroid adenoma and gene detection. The MEN1 patient's case was complicated with relapsed primary hyperparathyroidism (PHPT), and they received ultrasound-guided radiofrequency ablation (RFA). The patient had a remarkable recovery after RFA treatment for the relapsed PHPT. It might be an alternative treatment for MEN1 patients with poor conditions such as high surgical risk, unwillingness to choose parathyroid surgery or those unable to tolerate surgery. Individualized therapy significantly benefits the prognosis of MEN1 patients.

摘要

多发性内分泌腺瘤1型（MEN1）是一种以两个或更多内分泌腺肿瘤发作为特征的综合征。在此，我们展示了一例通过胃泌素瘤、甲状旁腺腺瘤和基因检测被诊断为MEN1的52岁男性病例。该MEN1患者的病例并发复发性原发性甲状旁腺功能亢进症（PHPT），并接受了超声引导下的射频消融（RFA）治疗。经RFA治疗复发性PHPT后，患者恢复显著。对于手术风险高、不愿选择甲状旁腺手术或无法耐受手术等病情较差的MEN1患者，这可能是一种替代治疗方法。个体化治疗对MEN1患者的预后有显著益处。