Endocrine and Diabetes Center, The Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China.
Department of Ultrasound, The Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China.
Front Endocrinol (Lausanne). 2023 Sep 19;14:1175377. doi: 10.3389/fendo.2023.1175377. eCollection 2023.
Multiple endocrine neoplasia type 1 (MEN1) is an inherited endocrine syndrome caused by the mutation in the tumor suppressor gene . The recurrence rate of primary hyperparathyroidism (PHPT) in patients with MEN1 after parathyroidectomy remains high, and the management of recurrent hyperparathyroidism is still challenging.
We reported a 44-year-old woman with MEN1 combined with PHPT who was diagnosed through genetic screening of the patient and her family members. After parathyroidectomy to remove one parathyroid gland, the patient suffered from persistent high levels of serum calcium and parathyroid hormone, which returned to normal at up to 8 months after ultrasound-guided microwave ablation (MWA) for bilateral parathyroid glands, suggesting an acceptable short-term prognosis.
Ultrasound-guided MWA for parathyroid nodules may be an effective therapeutic strategy for recurrent PHPT in MEN1 patients.
多发性内分泌腺瘤病 1 型（MEN1）是一种由肿瘤抑制基因 突变引起的遗传性内分泌综合征。MEN1 患者甲状旁腺切除术后原发性甲状旁腺功能亢进症（PHPT）的复发率仍然很高，复发性甲状旁腺功能亢进症的管理仍然具有挑战性。
我们报告了一例 44 岁的 MEN1 合并 PHPT 女性患者，该患者通过对患者及其家庭成员进行基因筛查而确诊。甲状旁腺切除术后切除了一个甲状旁腺，患者的血清钙和甲状旁腺激素持续升高，在双侧甲状旁腺超声引导微波消融（MWA）后长达 8 个月才恢复正常，提示短期预后尚可。
超声引导 MWA 治疗甲状旁腺结节可能是 MEN1 患者复发性 PHPT 的有效治疗策略。
