Trisler D, Collins F
Science. 1987 Sep 4;237(4819):1208-9. doi: 10.1126/science.3629237.
The topographic map of cell position in the avian retina is inverted in its projection to the optic tectum. Dorsal retinal ganglion cell axons project to ventral tectum, and ventral retinal ganglion cells project to dorsal tectum. Topographic gradients of toponymic (TOP) cell surface molecules along the dorsoventral axes of retina and tectum also are inverted. TOP molecules are most abundant in dorsal retina and ventral tectum and least abundant in ventral retina and dorsal tectum during the period of initial retinal-tectal interaction. Thus, TOP molecules may be involved in orienting the retinotectal map.
鸟类视网膜中细胞位置的地形图在其投射到视顶盖时是倒置的。视网膜背侧神经节细胞轴突投射到视顶盖腹侧，而视网膜腹侧神经节细胞投射到视顶盖背侧。沿视网膜和视顶盖背腹轴的地名（TOP）细胞表面分子的拓扑梯度也呈倒置状态。在视网膜 - 视顶盖初始相互作用期间，TOP分子在视网膜背侧和视顶盖腹侧最为丰富，而在视网膜腹侧和视顶盖背侧最为稀少。因此，TOP分子可能参与了视网膜 - 视顶盖图谱的定向过程。
