Pharma Nord (UK) Ltd., Morpeth NE61 2DB, UK.
School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Merseyside L3 5UX, UK.
Int J Mol Sci. 2022 Oct 20;23(20):12603. doi: 10.3390/ijms232012603.
Mitochondrial dysfunction has been implicated in the pathogenesis of a number of neurodegenerative disorders, including Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, multisystem atrophy, and progressive supranuclear palsy. This article is concerned specifically with mitochondrial dysfunction as defined by reduced capacity for ATP production, the role of depleted levels of key nutritionally related metabolites, and the potential benefit of supplementation with specific nutrients of relevance to normal mitochondrial function in the above neurodegenerative disorders. The article provides a rationale for a combination of CoQ10, B-vitamins/NADH, L-carnitine, vitamin D, and alpha-lipoic acid for the treatment of the above neurodegenerative disorders.
线粒体功能障碍与许多神经退行性疾病的发病机制有关,包括帕金森病、阿尔茨海默病、肌萎缩侧索硬化症、多系统萎缩症和进行性核上性麻痹。本文特别关注线粒体功能障碍,具体表现为 ATP 生成能力下降、关键营养相关代谢物水平降低,以及补充与上述神经退行性疾病正常线粒体功能相关的特定营养素的潜在益处。本文为使用 CoQ10、B 族维生素/NADH、左旋肉碱、维生素 D 和硫辛酸联合治疗上述神经退行性疾病提供了理论依据。