Leipner N, Köster O, Rouwen D, Hartlapp J, Hansen H
Strahlenther Onkol. 1987 Aug;163(8):534-43.
Liver metastases of colorectal carcinomas were diagnosed by computed tomography in 116 patients. Several control examinations were made during the course of the disease. The therapeutic effect on the metastases is defined by measurements of the tissular density. Patients submitted to dearterialization or local chemotherapy showed a higher incidence of regressive tumor calcifications and necroses than untreated patients ans patients treated by systemic chemotherapy. The median survival of the untreated patients is 3.6 months, patients treated by systemic chemotherapy have a median survival of 7.9 months, and patients submitted to dearterialization and local chemotherapy show a median survival of 15.7 months. Patients treated by resection survived 36 months, which is about 10 months longer than the survival of patients treated by dearterialization, considering comparable metastatic stages. An increased survival after systemic chemotherapy was only observed in patients of stage 1.
116例结直肠癌肝转移患者通过计算机断层扫描确诊。在疾病过程中进行了多次对照检查。转移灶的治疗效果通过组织密度测量来定义。接受去动脉化或局部化疗的患者与未治疗患者及接受全身化疗的患者相比，肿瘤钙化和坏死的发生率更高。未治疗患者的中位生存期为3.6个月，接受全身化疗的患者中位生存期为7.9个月，接受去动脉化和局部化疗的患者中位生存期为15.7个月。接受手术切除的患者存活36个月，考虑到可比的转移阶段，这比接受去动脉化治疗的患者的生存期长约10个月。仅在1期患者中观察到全身化疗后生存期延长。
