Unit for Human Reproduction, 1st Department of Obstetrics & Gynaecology, Aristotle University Medical School, Papageorgiou General Hospital, 56403 Thessaloniki, Greece.
Biology Department, SUNY College at Old Westbury, Old Westbury, NY 11731, USA.
Medicina (Kaunas). 2022 Oct 20;58(10):1493. doi: 10.3390/medicina58101493.
: Preimplantation genetic testing (PGT) offers patients the possibility of having a healthy baby free of chromosomal or genetic disorders. The present study focuses on the application of PGT for patients located in Northern Greece, investigating their clinical outcomes, their motives, and their overall physical and emotional experience during the treatment, in association with their socioeconomic background. : Couples who underwent PGT for a monogenic condition (PGT-M, = 19 cycles) or aneuploidy (PGT-A, = 22 cycles) participated in the study. Fertilization, implantation, and pregnancy rates were recorded for all cycles. The couples were asked to fill in a questionnaire about the consultation they had received prior to treatment, their sociodemographic information, and the psychological impact PGT had on both the female and male partner. : The fertilization, implantation, and ongoing pregnancy rates for the PGT-M and PGT-A cycles were 81.3%, 70.6%, and 52.9%, and 78.2%, 64.3%, and 57.1%, respectively. Females experienced more intense physical pain than their male partners while psychological pain was encountered by both partners and occasionally in higher instances in males. No typical socioeconomic background of the patients referred for PGT in Northern Greece was noticed. : PGT is an attractive alternative to prenatal diagnosis (PND), aiming to establisha healthy pregnancy by identifying and avoiding the transfer of chromosomally or genetically abnormal embryos to the uterus. Although the benefits of PGT were well-received by all patients undergoing the procedure, psychological pain was evident and especially prominent in patients with a previous affected child or no normal embryos for transfer. Holistic counseling is of utmost importance in order to make patients' experience during their journey to have a healthy baby less emotionally demanding and help them make the right choices for the future.
胚胎植入前遗传学检测（PGT）为患者提供了生育无染色体或遗传疾病的健康婴儿的可能性。本研究侧重于在希腊北部为患者应用 PGT，调查他们的临床结果、他们的动机以及他们在治疗过程中的整体身体和情感体验，同时考虑他们的社会经济背景。
进行单基因疾病（PGT-M，=19 个周期）或非整倍体（PGT-A，=22 个周期）PGT 的夫妇参加了这项研究。记录了所有周期的受精、着床和妊娠率。夫妇们被要求填写一份关于他们在治疗前接受的咨询、他们的社会人口统计学信息以及 PGT 对女性和男性伴侣的心理影响的问卷。
PGT-M 和 PGT-A 周期的受精、着床和持续妊娠率分别为 81.3%、70.6%和 52.9%和 78.2%、64.3%和 57.1%。女性比男性伴侣经历更强烈的身体疼痛，而心理疼痛则由双方伴侣共同经历，偶尔在男性中更为严重。在希腊北部，没有注意到患者接受 PGT 的典型社会经济背景。
PGT 是产前诊断（PND）的一种有吸引力的替代方法，旨在通过识别和避免将染色体或遗传异常的胚胎转移到子宫中来建立健康的妊娠。虽然所有接受该程序的患者都对 PGT 的益处表示欢迎，但心理疼痛明显存在，尤其是在有先前受影响的孩子或没有正常胚胎可转移的患者中更为明显。综合咨询至关重要，以便使患者在生育健康婴儿的过程中减少情感需求，并帮助他们为未来做出正确的选择。
