Delio D A, Gold B G, Lowndes H E
Toxicol Appl Pharmacol. 1987 Sep 15;90(2):253-60. doi: 10.1016/0041-008x(87)90333-4.
Unusual electrical interactions between neuronal elements of cat spinal cord were examined during the evolution (7-70 days) of proximal paranodally demyelinated axonal enlargements in alpha motor axons induced by beta, beta'-iminodipropionitrile (IDPN) treatment, 50 mg/kg ip, once weekly for up to 5 weeks. The electrical cross talk was observed as early as 7 days of the neuropathy, at which time it occurred in 17.0% of all motoneuron perikaryal recordings. The incidence was greater at 14 (39.1%) and 35 (26.1%) days, without preferential involvement of any motoneuron type. The frequency of recordings from axonal swellings increased from 7 to 35 days but without an increase in cross talk per recording. At 70 days of the neuropathy, L7 ventral root was stimulated repetitively to examine a possible influence of potassium on cross talk. Subsequently, action potentials could be elicited in motoneurons by stimulation of additional other ventral root filaments. These studies are in agreement with the lack of direct electrical apposition between excitable membranes in IDPN neuropathy but suggest support for a role for an accumulation of extracellular potassium, due to paranodal demyelination as the axon enlarges, in the pathogenesis of these aberrant electrical interactions.
在用β，β'-亚氨基二丙腈（IDPN）处理诱导猫α运动轴突近端结旁脱髓鞘轴突肿胀的过程（7 - 70天）中，研究了猫脊髓神经元元件之间异常的电相互作用。IDPN腹腔注射剂量为50mg/kg，每周一次，共注射5周。早在神经病变的第7天就观察到了电串扰，此时在所有运动神经元胞体记录中，电串扰发生率为17.0%。在第14天（39.1%）和第35天（26.1%）时发生率更高，且未出现对任何运动神经元类型的优先累及。从轴突肿胀处记录的频率从第7天到第35天有所增加，但每次记录中的电串扰并未增加。在神经病变的第70天，反复刺激L7腹根以检查钾对电串扰的可能影响。随后，通过刺激其他腹根细丝可在运动神经元中引发动作电位。这些研究与IDPN神经病变中可兴奋膜之间缺乏直接电接触一致，但表明支持以下观点：随着轴突肿胀，结旁脱髓鞘导致细胞外钾积累，在这些异常电相互作用的发病机制中起作用。
