• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

台湾眼镜蛇(眼镜蛇)毒液中一种类心脏毒素碱性多肽对培养的骨骼肌细胞的去极化作用。

Depolarization of skeletal muscle cells in culture by a cardiotoxin-like basic polypeptide from the venom of the Taiwan cobra (naja naja atra).

作者信息

Harvey A L, Hayashi K

出版信息

Toxicon. 1987;25(6):681-4. doi: 10.1016/0041-0101(87)90116-4.

DOI:10.1016/0041-0101(87)90116-4
PMID:3629619
Abstract

A cardiotoxin-like basic polypeptide from the venom of Naja naja atra is homologous to cardiotoxins from the same venom, but much less toxic. To determine if it acts like the cardiotoxins its depolarizing ability was measured. It was about 10 times less potent than the cardiotoxins. Five amino acids are conserved in the sequences studied, on the exposed second and third loops of the toxin backbone. They may be part of the toxins' interactive site.

摘要

一种来自眼镜蛇毒的类心脏毒素碱性多肽与同一毒液中的心脏毒素同源,但毒性要小得多。为了确定它是否像心脏毒素那样起作用,对其去极化能力进行了测量。其效力比心脏毒素低约10倍。在所研究的序列中,毒素主链暴露的第二个和第三个环上有五个氨基酸是保守的。它们可能是毒素相互作用位点的一部分。

相似文献

1
Depolarization of skeletal muscle cells in culture by a cardiotoxin-like basic polypeptide from the venom of the Taiwan cobra (naja naja atra).台湾眼镜蛇(眼镜蛇)毒液中一种类心脏毒素碱性多肽对培养的骨骼肌细胞的去极化作用。
Toxicon. 1987;25(6):681-4. doi: 10.1016/0041-0101(87)90116-4.
2
The multiplicity of cardiotoxins from Naja naja atra (Taiwan cobra) venom.中华眼镜蛇(台湾眼镜蛇)毒液中心脏毒素的多样性。
Toxicon. 2000 Aug;38(8):1065-76. doi: 10.1016/s0041-0101(99)00218-4.
3
Effect of phospholipase A on actions of cobra venom cardiotoxins on erythrocytes and skeletal muscle.磷脂酶A对眼镜蛇毒心脏毒素作用于红细胞和骨骼肌的影响。
Biochim Biophys Acta. 1983 Feb;728(2):215-21. doi: 10.1016/0005-2736(83)90474-1.
4
Six isoforms of cardiotoxin in malayan spitting cobra (Naja naja sputatrix) venom: cloning and characterization of cDNAs.马来喷毒眼镜蛇(Naja naja sputatrix)毒液中六种心脏毒素同工型:cDNA的克隆与特性分析
Biochim Biophys Acta. 1998 Apr 10;1380(2):209-22. doi: 10.1016/s0304-4165(97)00143-8.
5
Effects of different antagonists on depolarization of cultured chick myotubes by cobra venom cardiotoxins and Pyrularia thionin from the plant Pyrularia pubera.不同拮抗剂对眼镜蛇毒心脏毒素及来自柔毛油丹植物的油丹硫素所致培养鸡肌管去极化的影响。
Toxicon. 1993 Oct;31(10):1229-36. doi: 10.1016/0041-0101(93)90396-z.
6
Effects of purified cardiotoxins from the Thailand cobra (Naja naja siamensis) on isolated skeletal and cardiac muscle preparations.泰国眼镜蛇(眼镜蛇指名亚种)纯化的心脏毒素对离体骨骼肌和心肌标本的影响。
Toxicon. 1982;20(2):379-96. doi: 10.1016/0041-0101(82)90001-0.
7
Factors influencing the hemolysis of human erythrocytes by cardiotoxins from Naja naja kaouthia and Naja naja atra venoms and a phospholipase A2 with cardiotoxin-like activities from Bungarus fasciatus venom.影响眼镜王蛇毒和眼镜蛇毒中的心毒素以及银环蛇毒中具有心毒素样活性的磷脂酶A2对人红细胞溶血作用的因素。
Toxicon. 1989;27(2):247-57. doi: 10.1016/0041-0101(89)90138-4.
8
Amino acid sequence of a cardiotoxin-like basic polypeptide (CLBP) with low cytotoxic activity isolated from the venom of the Formosan cobra (Naja naja atra).从台湾眼镜蛇(Naja naja atra)毒液中分离出的具有低细胞毒性活性的类心脏毒素碱性多肽(CLBP)的氨基酸序列。
Biochem Int. 1985 Dec;11(6):795-802.
9
Hemolytic activity of thionin from Pyrularia pubera nuts and snake venom toxins of Naja naja species: Pyrularia thionin and snake venom cardiotoxin compete for the same membrane site.毛叶鱼藤果仁中硫堇的溶血活性及眼镜蛇属蛇毒毒素:毛叶鱼藤硫堇与蛇毒心脏毒素竞争同一膜位点。
Toxicon. 1989;27(5):511-7. doi: 10.1016/0041-0101(89)90112-8.
10
Improved method for the isolation, characterization and examination of neuromuscular and toxic properties of selected polypeptide fractions from the crude venom of the Taiwan cobra Naja naja atra.从台湾眼镜蛇(Naja naja atra)粗毒中分离、鉴定和研究特定多肽片段的神经肌肉毒性的改良方法。
Toxicon. 2012 Sep 15;60(4):623-31. doi: 10.1016/j.toxicon.2012.05.013. Epub 2012 Jun 4.

引用本文的文献

1
Isolation, purification, crystallization and preliminary crystallographic studies of sagitoxin, an oligomeric cardiotoxin from the venom of Naja naja saggitifera.舟山眼镜蛇毒液中寡聚心脏毒素箭毒素的分离、纯化、结晶及初步晶体学研究
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jun 1;64(Pt 6):545-7. doi: 10.1107/S1744309108014334. Epub 2008 May 24.