丙酮对N-(3,5-二氯苯基)琥珀酰亚胺诱导的肾毒性的影响。

Acetone effects on N-(3,5-dichlorophenyl)succinimide-induced nephrotoxicity.

作者信息

Lo H H, Teets V J, Yang D J, Brown P I, Rankin G O

出版信息

Toxicol Lett. 1987 Sep;38(1-2):161-8. doi: 10.1016/0378-4274(87)90124-x.

Abstract

Acetone has been shown to potentiate the toxicity of many halogenated hydrocarbons. The purpose of this study was to determine if acetone could alter the acute nephrotoxicity produced by the experimental fungicide N-(3,5-dichlorophenyl)succinimide (NDPS). Male Fischer 344 rats were administered acetone (1, 5 or 10 mmol/kg) or acetone vehicle (corn oil, 10 mg/kg) orally followed 16 h later by a single intraperitoneal injection of NDPS (0.2 or 0.4 mmol/kg) or NDPS vehicle (sesame oil, 2.5 ml/kg) and renal function was monitored at 24 and 48 h. Acetone (1 or 5 mmol/kg) did not alter NDPS (0.2 mmol/kg)-induced renal effects while acetone (10 mmol/kg) pretreatment attenuated NDPS (0.4 mmol/kg)-induced increases in blood urea nitrogen (BUN) concentration and kidney weight but had no effect on NDPS (0.4 mol/kg)-induced changes in urine volume or content, organic ion accumulation by renal cortical slices or renal morphology. These results suggest that acetone weakly attenuates NDPS-induced nephrotoxicity.

摘要

已证实丙酮可增强多种卤代烃的毒性。本研究的目的是确定丙酮是否会改变实验性杀菌剂N-(3,5-二氯苯基)琥珀酰亚胺（NDPS）产生的急性肾毒性。给雄性Fischer 344大鼠口服丙酮（1、5或10 mmol/kg）或丙酮载体（玉米油，10 mg/kg），16小时后腹腔注射单次剂量的NDPS（0.2或0.4 mmol/kg）或NDPS载体（芝麻油，2.5 ml/kg），并在24小时和48小时监测肾功能。丙酮（1或5 mmol/kg）未改变NDPS（0.2 mmol/kg）诱导的肾脏效应，而丙酮（10 mmol/kg）预处理减弱了NDPS（0.4 mmol/kg）诱导的血尿素氮（BUN）浓度升高和肾脏重量增加，但对NDPS（0.4 mol/kg）诱导的尿量或尿成分变化、肾皮质切片有机离子蓄积或肾脏形态没有影响。这些结果表明丙酮可轻度减弱NDPS诱导的肾毒性。