Haberman P J, Baggett J M, Berndt W O
Toxicol Lett. 1987 Sep;38(1-2):83-90. doi: 10.1016/0378-4274(87)90114-7.
Previous studies in this laboratory revealed an effect of chromate to potentiate the nephrotoxic effects of mercuric ion. Citrinin, an organic anion, is a known nephrotoxin. The present study was undertaken to assess the possible interaction of chromate and citrinin on renal function. Male Sprague-Dawley rats were housed in metabolism cages and injected with citrinin (35 mg/kg), chromate (10 mg/kg) or the combination. The combination of nephrotoxicants caused an increased excretion of urine greater than the sum of the individual responses. A similar response was observed with urinary glucose concentrations and glucose excretion without changes in blood glucose levels. These data indicate that chromate can potentiate the nephrotoxic action of citrinin in the rat.
本实验室之前的研究揭示了铬酸盐增强汞离子肾毒性作用的效应。桔霉素是一种有机阴离子，是一种已知的肾毒素。本研究旨在评估铬酸盐和桔霉素对肾功能可能的相互作用。将雄性斯普拉格-道利大鼠饲养在代谢笼中，并注射桔霉素（35毫克/千克）、铬酸盐（10毫克/千克）或两者的组合。肾毒物的组合导致尿量排泄增加，大于各单独反应之和。在尿葡萄糖浓度和葡萄糖排泄方面观察到类似反应，而血糖水平无变化。这些数据表明，铬酸盐可增强桔霉素对大鼠的肾毒性作用。
