Synthesis, In Vitro Anti-Microbial Analysis and Molecular Docking Study of Aliphatic Hydrazide-Based Benzene Sulphonamide Derivatives as Potent Inhibitors of α-Glucosidase and Urease.

A unique series of sulphonamide derivatives was attempted to be synthesized in this study using a new and effective method. All of the synthesized compounds were verified using several spectroscopic methods, including FTIR, H-NMR, C-NMR, and HREI-MS, and their binding interactions were studied using molecular docking. The enzymes urease and α-glucosidase were evaluated against each derivative (-). When compared to their respective standard drug such as acarbose and thiourea, almost all compounds were shown to have excellent activity. Among the screened series, analogs (IC = 3.20 ± 0.40 and 2.10 ± 0.10 µM) and (IC = 2.50 ± 0.40 and 5.30 ± 0.20 µM), emerged as potent molecules when compared to the standard drugs acarbose (IC = 8.24 ± 0.08 µM) and urease (IC = 7.80 ± 0.30). Moreover, an anti-microbial study also demonstrated that analogs and were found with minimum inhibitory concentrations (MICs) in the presence of standard drugs streptomycin and terinafine.