Marcus C S, Myhre B A, Angulo M C, Salk R D, Essex C E, Demianew S H
Transfusion. 1987 Sep-Oct;27(5):415-9. doi: 10.1046/j.1537-2995.1987.27587320536.x.
The simultaneous determination of autologous 99mTc red cell (RBC) and 51Cr RBC viability at 24 hours was measured in 19 normal volunteers whose RBCs had been stored in additive media (Nutracel) for 42 or 49 days. The ratio of the 51Cr:99mTc value was 1.23. In this experiment we also calculated 51Cr RBC viability by both the single-isotope method (extrapolation) and the double-isotope method (using 125I human serum albumin for an independent plasma volume) in the same volunteers. The corresponding viability values were not significantly different. The simultaneous determination of autologous 111In-oxine RBC and 51Cr RBC viability at 24 hours was measured in 19 other normal volunteers whose RBCs had been stored in citrate-phosphate-dextrose-adenine (CPDA-1) for 1 or 15 days. The ratio of the 51Cr:111In value was 1.1. Use of these 24-hour viability ratios as conversion factors permits direct comparison of 99mTc or 111In RBC viability with a 51Cr standard, and therefore expands the application of these newer RBC radiolabels.
在19名正常志愿者中测量了自体99mTc红细胞（RBC）和51Cr红细胞在24小时时的活力，这些志愿者的红细胞已在添加剂培养基（Nutracel）中储存42或49天。51Cr:99mTc值的比率为1.23。在本实验中，我们还通过单同位素法（外推法）和双同位素法（使用125I人血清白蛋白测定独立的血浆容量）在相同志愿者中计算了51Cr红细胞活力。相应的活力值无显著差异。在另外19名正常志愿者中测量了自体111In-奥克辛红细胞和51Cr红细胞在24小时时的活力，这些志愿者的红细胞已在枸橼酸盐-磷酸盐-葡萄糖-腺嘌呤（CPDA-1）中储存1或15天。51Cr:111In值的比率为1.1。将这些24小时活力比率用作转换因子，可以将99mTc或111In红细胞活力与51Cr标准进行直接比较，因此扩大了这些新型红细胞放射性标记物的应用。
