Saidi N, Azzaoui K, Ramdani M, Mejdoubi E, Jaradat N, Jodeh S, Hammouti B, Sabbahi R, Lamhamdi A
Laboratory of Applied Chemistry and Environment (LCAE), Department of Chemistry, Faculty of Sciences, University Mohamed I, Oujda P.O. Box 717, Morocco.
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus P.O. Box 7, Palestine.
Polymers (Basel). 2022 Oct 20;14(20):4446. doi: 10.3390/polym14204446.
Hydroxyapatite (HAp) attracts interest as a biomaterial for use in bone substitution or allografts. In the current work, biomaterial nanocomposites based on HAp and pectin were synthesized by using the double decomposition method, which involved using pectin extracted from fresh cladodes of the prickly pear, . The crystallinity, purity, and several analytical techniques like Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy were used to understand the surface's shape. The results revealed that the produced HAp/pectin nanoparticles are pure, spherical, and amorphous. The spectroscopic data indicated a substantial interaction between HAp and pectin, specifically between Ca (II) and pectin hydroxyl and carboxyl groups. The presence of pectin showed a noticeable influence on the prepared nanocomposite texture and porosity. We further assess the antibacterial and antifungal activity of the developed nanocomposite against a number of pathogenic bacteria and fungi, evaluated by the well diffusion method. In the absence of pectin, the XRD analysis revealed that the HAp nanoparticles had 10.93% crystallinity. When the pectin concentration reached 10 wt.%, it was reduced to approximately 7.29%. All synthesized nanocomposites demonstrated strong antimicrobial activity against both Gram-positive ( and ) and Gram-negative ( and ) bacteria in addition to various fungi (e.g., , , and ). This study endorses the HAp/Pectin nanocomposite as an efficient antimicrobial material for biomedical advanced applications.
羟基磷灰石（HAp）作为一种用于骨替代或同种异体移植的生物材料备受关注。在当前工作中，采用复分解法合成了基于HAp和果胶的生物材料纳米复合材料，该方法涉及使用从仙人掌新鲜茎片中提取的果胶。利用结晶度、纯度以及傅里叶变换红外光谱、X射线衍射和扫描电子显微镜等多种分析技术来了解其表面形状。结果表明，所制备的HAp/果胶纳米颗粒是纯净的、球形的且无定形的。光谱数据表明HAp与果胶之间存在显著相互作用，特别是Ca（II）与果胶的羟基和羧基之间。果胶的存在对所制备的纳米复合材料的质地和孔隙率有显著影响。我们进一步评估了所开发的纳米复合材料对多种致病细菌和真菌的抗菌和抗真菌活性，采用琼脂扩散法进行评估。在没有果胶的情况下，XRD分析表明HAp纳米颗粒的结晶度为10.93%。当果胶浓度达到10 wt.%时，结晶度降低至约7.29%。所有合成的纳米复合材料除了对各种真菌（如、和）具有强抗菌活性外，对革兰氏阳性菌（和）和革兰氏阴性菌（和）也具有强抗菌活性。本研究认可HAp/果胶纳米复合材料作为一种用于生物医学先进应用的高效抗菌材料。
Zotero 插件
