Laboratory of Applied Chemistry and Environment (LCAE), Faculty of Sciences, University Mohammed Premier, PB 4808, Oujda 60046, Morocco.
Centre de Recherche, Ecole des Hautes Etudes d'Ingénierie EHEIO, Oujda 60046, Morocco.
Molecules. 2022 Feb 19;27(4):1408. doi: 10.3390/molecules27041408.
The need for biodegradable and biocompatible polymers is growing quickly, particularly in the biomedical and environmental industries. Cellulose acetate, a natural polysaccharide, can be taken from plants and modified with polycaprolactone to improve its characteristics for a number of uses, including biomedical applications and food packaging. Cellulose acetate-g-polycaprolactone was prepared by a three-step reaction: First, polymerization of ε-caprolactone via ring-opening polymerization (ROP) reaction using 2-hydroxyethyl methacrylate (HEMA) and functionalization of polycaprolactone(PCL) by introducing NCO on the hydroxyl end of the HEMA-PCL using hexamethyl lenediisocyanate(HDI) were carried out. Then, the NCO-HEMA-PCL was grafted onto cellulose acetate (using the "grafting to" method). The polycaprolactone grafted cellulose acetate was confirmed by FTIR, the thermal characteristics of the copolymers were investigated by DSC and TGA, and the hydrophobicity was analyzed via water CA measurement. Introducing NCO-PCL to cellulose acetate increased the thermal stability. The contact angle of the unreacted PCL was higher than that of cellulose acetate-g-PCL, and it increased when the chain length increased. The CA-g-PCL50, CA-g-PCL100, and CA-g-PCL200 showed very high inhibition zones for all three bacteria tested (, , and ).
对可生物降解和生物相容聚合物的需求迅速增长，特别是在生物医学和环境行业。醋酸纤维素是一种天然多糖，可以从植物中提取出来，并与聚己内酯进行改性，以改善其在许多用途中的特性，包括生物医学应用和食品包装。醋酸纤维素-g-聚己内酯是通过三步反应制备的：首先，通过开环聚合（ROP）反应聚合ε-己内酯，使用 2-羟乙基甲基丙烯酸酯（HEMA），并通过在 HEMA-聚己内酯的羟基末端引入 NCO 来官能化聚己内酯（PCL）使用六亚甲基二异氰酸酯（HDI）。然后，将 NCO-HEMA-PCL 接枝到醋酸纤维素上（使用“接枝到”方法）。通过傅里叶变换红外光谱（FTIR）证实了共聚物的接枝，通过差示扫描量热法（DSC）和热重分析（TGA）研究了共聚物的热特性，并通过水 CA 测量分析了疏水性。将 NCO-PCL 引入醋酸纤维素增加了热稳定性。未反应的 PCL 的接触角高于纤维素醋酸酯-g-PCL，并且当链长增加时接触角增加。CA-g-PCL50、CA-g-PCL100 和 CA-g-PCL200 对所有三种测试的细菌（，和）均显示出非常高的抑菌圈。
