Wu Zhenguo, Su Guanli, Lu Wenting, Liu Lin, Zhou Zixuan, Xie Bingchuan
Department of Psychiatry, The First Hospital of Hebei Medical University, Shijiazhuang, China.
Mental Health Institute of the Hebei Medical University, Shijiazhuang, China.
Front Psychiatry. 2022 Oct 10;13:1009653. doi: 10.3389/fpsyt.2022.1009653. eCollection 2022.
To evaluate the correlation between clinical symptoms and cognitive impairment in elderly patients with depressive disorder.
In this retrospective study, a total of 123 elderly patients with depressive disorder admitted to our hospital from January 2020 to February 2021 were included. Patients' cognitive function was assessed by the Montreal Cognitive Assessment Scale (MoCA). According to the combination of cognitive impairment or not, patients were divided into the combined group (64 cases) and the depressive disorder group (59 cases). In addition, 70 healthy people who came to our hospital for physical examination during the same period were randomly selected as the healthy group.
The incidence of severe cognitive impairment in the combined group (33, 51.56%) was significantly higher than that in the depression group (19, 32.20%), the difference was statistically significant ( = 0.003). The incidence of somatization symptoms, suicidal tendency, retardation of thinking, diminution of energy, anxiety and sleep disorder in the combined group were higher than that in the depressive disorder group with significant difference [30 (56.88%) vs. 16 (27.12%), = 0.024; 12 (18.75%) vs. 3 (5.08%), = 0.021; 33 (51.56%) vs. 14 (23.73%), = 0.002; 37 (57.81%) vs. 23 (38.98%), = 0.029; 42 (65.63) vs. 25 (42.37), = 0.011; 50 (78.13) vs. 42 (71.19), = 0.031, respectively]. Spearman rank correlation analysis suggested that somatic symptom, mood change, suicidal tendency, retardation of thinking, diminution of energy, anxiety, and sleep disorder were negatively correlated with cognitive impairment, respectively ( =-0.161, -0.672, -0.262, -0.871, -0.421, -0.571, -0.512, < 0.001).
The clinical symptoms of depressive disorder were negatively correlated with cognitive impairment. Somatic symptoms, suicidal tendency, retardation of thinking, diminution of energy, anxiety, and sleep disorder were the risk factors for cognitive impairment.
评估老年抑郁症患者临床症状与认知障碍之间的相关性。
在这项回顾性研究中，纳入了2020年1月至2021年2月期间我院收治的123例老年抑郁症患者。采用蒙特利尔认知评估量表（MoCA）对患者的认知功能进行评估。根据是否合并认知障碍，将患者分为合并组（64例）和抑郁症组（59例）。此外，随机选取同期来我院体检的70名健康人作为健康组。
合并组严重认知障碍发生率（33例，51.56%）显著高于抑郁症组（19例，32.20%），差异有统计学意义（ = 0.003）。合并组躯体化症状、自杀倾向、思维迟缓、精力减退、焦虑及睡眠障碍的发生率均高于抑郁症组，差异有统计学意义[30例（56.88%）对16例（27.12%）， = 0.024；12例（18.75%）对3例（5.08%）， = 0.021；33例（51.56%）对14例（23.73%）， = 0.002；37例（57.81%）对23例（38.98%）， = 0.029；42例（65.63%）对25例（42.37%）， = 0.011；50例（78.13%）对42例（71.19%）， = 0.031]。Spearman等级相关分析表明，躯体症状、情绪变化、自杀倾向、思维迟缓、精力减退、焦虑及睡眠障碍与认知障碍分别呈负相关（ = -0.161、-0.672、-0.262、-0.871、-0.421、-0.571、-0.512， < 0.001）。
抑郁症临床症状与认知障碍呈负相关。躯体症状、自杀倾向、思维迟缓、精力减退、焦虑及睡眠障碍是认知障碍的危险因素。
