Bruss Zachary, Farook Shanza, Shah Sana, Baker Sheikh Abu
Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Department of Internal Medicine, Shifa International Hospital, Islamabad, Pakistan.
Eur J Case Rep Intern Med. 2022 Sep 22;9(9):003565. doi: 10.12890/2022_003565. eCollection 2022.
Sirolimus is an inhibitor of the mammalian target of rapamycin, which is used in kidney transplant immunosuppression. The clinical spectrum of cutaneous adverse events associated with sirolimus use varies, with maculopapular rash being an uncommon side effect very rarely reported in the literature. We present the case of a 78-year-old male renal transplant recipient who developed a diffuse maculopapular pruritic rash after starting sirolimus. This case report demonstrates that maculopapular rash is an uncommon sirolimus-related side effect that must be identified promptly so the medication can be discontinued and rash progression prevented.
Acneiform dermatitis, folliculitis, onychopathy, oral ulcers, rash and stomatitis are all common dermatological side effects of sirolimus.The occurrence of a diffuse pruritic maculopapular rash associated with sirolimus use is rare, but an important differential to keep in mind.Sirolimus cessation is required in case of diffuse pruritic maculopapular rash.
西罗莫司是哺乳动物雷帕霉素靶蛋白的抑制剂，用于肾移植免疫抑制。与使用西罗莫司相关的皮肤不良事件临床谱各异，斑丘疹是一种不常见的副作用，在文献中很少报道。我们报告一例78岁男性肾移植受者，在开始使用西罗莫司后出现弥漫性斑丘疹伴瘙痒。本病例报告表明，斑丘疹是一种不常见的与西罗莫司相关的副作用，必须及时识别，以便停用药物并防止皮疹进展。
痤疮样皮炎、毛囊炎、甲病、口腔溃疡、皮疹和口腔炎都是西罗莫司常见的皮肤副作用。使用西罗莫司后出现弥漫性瘙痒性斑丘疹很少见，但需重点鉴别。出现弥漫性瘙痒性斑丘疹时需要停用西罗莫司。
