Internal Medicine Department, La Ribera University Hospital, Alzira, Valencia, Spain.
Servicio de Medicina Interna, Hospital Universitario de La Ribera, Alzira, Valencia, Spain.
J Med Microbiol. 2022 Oct;71(10). doi: 10.1099/jmm.0.001599.
. The possibility of reinfection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a widely proven fact and may have clinical implications.. It is not known whether there have been cases of reinfection by SARS-CoV-2 in La Ribera Health Department. To determine whether there have been cases of reinfection by SARS-CoV-2 in La Ribera Health Department and to identify their characteristics.. Retrospective cross-sectional observational study of cases of reinfection by SARS-CoV-2 in the population of La Ribera Department between March 2020 and February 2021. The positive baseline cohort includes all cases positive by RT-PCR for SARS-CoV-2, with reinfection cases being those that, after resolution of the first episode according to the World Health Organization (WHO) criteria, presented a new positive RT-PCR result.. Out of a total of 15 687 cases with positive RT-PCR, 40 were considered to be reinfections, which meant a cumulative incidence of 0.255 % and an incidence density of 5.05 cases per 100 000 person-days. Most of the cases occurred during the highest incidence peaks of the pandemic in the department. Seventy-five per cent of the patients in these cases were older than 40 years, 42.5 % were healthcare professionals or nursing home residents and 12.5 % had an immunosuppressive comorbidity. There were no severe, critical or death cases. In the reinfection episodes, with respect to the first episode, there was a tendency to be milder, they required fewer days of hospitalization, their RT-PCR became negative earlier, they developed a greater humoral response and the sick leave period was shorter. The median period between the RT-PCR in the first episode and the RT-PCR in the second episode was 127.5 days (range: 48-301; IQR: 89.5-256.25). SARS-CoV-2 reinfection cases are rare, tend to be mild and can occur within a median period of 127.5 days.
. 严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 再次感染的可能性是一个已被广泛证实的事实，并且可能具有临床意义。. 目前尚不清楚拉·里贝拉卫生局是否有 SARS-CoV-2 再次感染病例。. 目的 确定拉·里贝拉卫生局是否有 SARS-CoV-2 再次感染病例，并确定其特征。. 这是一项对 2020 年 3 月至 2021 年 2 月期间拉·里贝拉卫生局人群中 SARS-CoV-2 再次感染病例的回顾性横断面观察性研究。基线阳性队列包括所有通过 RT-PCR 检测 SARS-CoV-2 呈阳性的病例，再感染病例是指根据世界卫生组织 (WHO) 标准首次发作缓解后，新出现 RT-PCR 阳性结果的病例。. 在总共 15687 例 RT-PCR 阳性病例中，有 40 例被认为是再感染，这意味着累计发病率为 0.255%，发病率密度为每 100000 人-日 5.05 例。大多数病例发生在该部门大流行期间发病率最高的高峰期。这些病例中有 75%的患者年龄大于 40 岁，42.5%为医护人员或疗养院居民，12.5%有免疫抑制合并症。没有严重、危急或死亡病例。在再感染发作中，与首次发作相比，病情趋于较轻，住院天数较少，RT-PCR 更早转为阴性，产生更大的体液反应，病假时间较短。首次 RT-PCR 与第二次 RT-PCR 之间的中位时间为 127.5 天（范围：48-301；IQR：89.5-256.25）。SARS-CoV-2 再感染病例罕见，倾向于轻症，可在 127.5 天的中位时间内发生。
