Teichmann W, Brix E, Meyer E, Stabenow I, Panzner B, Busse H J, Krebbel A, Hagert M, Metzner H, Rode B
Z Gesamte Inn Med. 1987 May 1;42(9):235-8.
In 50 patients with acute infarction who were admitted within 6 hours after the beginning of the complaints randomizedly an intravenous streptokinase short-term lysis or a conventional heparin phenprocoumon treatment was performed and 4 weeks later the results were objectified by coronarography and ventriculography. The patients were subdivided into 3 groups: 1. control group (without fibrinolysis), 2. early lysis (within 4 hours) and 3. late lysis (4-6 hours). Four weeks after the infarction the proportions of the open infarction vessels are approximately of the same size in all three groups, the functional results are best (end-diastolic pressure and kinetics of the cardiac wall) in the group of patients who underwent an early lysis. Successfully lysed patients with remaining residual stenosis must be regarded as particularly threatened by infarction and remain under special control (residual angina, ergometrically objectified exercise tolerance, perhaps coronarography) in the phase of rehabilitation.
对50例在出现症状后6小时内入院的急性梗死患者进行随机分组，分别给予静脉链激酶短期溶栓治疗或传统肝素苯丙香豆素治疗，4周后通过冠状动脉造影和心室造影对结果进行客观评估。患者被分为3组：1. 对照组（不进行纤溶治疗）；2. 早期溶栓组（4小时内）；3. 晚期溶栓组（4 - 6小时）。梗死后4周，所有三组梗死血管开通的比例大致相同，早期溶栓组患者的功能结果最佳（舒张末期压力和心肌壁动力学）。成功溶栓但仍有残余狭窄的患者在康复阶段必须被视为特别容易发生梗死，需接受特殊监测（残余心绞痛、运动试验客观评估的运动耐量，可能还需进行冠状动脉造影）。
