Salahaddin University-Erbil, Department of Chemistry, College of Science, Kurdistan Region 44001, Iraq.
J AOAC Int. 2023 Mar 1;106(2):285-295. doi: 10.1093/jaoacint/qsac133.
Hyoscine butylbromide is used as an antispasmodic in treating peptic ulcers, gastritis, and various disorders of the gastrointestinal tract that are characterized by spasms. It has also found employment for the relief of spasmodic conditions of the bile duct and urinary tract and for the treatment of dysmenorrhea.
In this study, the application of silver nanoparticles (Ag NPs) as a colorimetric probe for the fast, selective, and simple determination of hyoscine butylbromide was described.
The proposed method was based on the Ag NPs aggregation induced by their interaction with the cited drug. This interaction produced a color change from yellow to colorless measured at 405 nm.
The method linear concentration range was 0.10-50.0 µg/mL with a correlation equation (y = 0.0132 x + 0.3174), correlation coefficient of 0.9981, and quantification limits of 0.091 µg/mL. A thorough investigation was done to validate the method's analytical performance, and the findings were satisfactory. With great accuracy and precision, this approach was used to identify the medication in pharmaceutical tablet samples with recovery percentages ranging from 96.20 to 98.10%.
Since there are no critical reaction conditions or solvent extraction involved in the described method, it is distinguished by its simplicity. The results were quite consistent with those attained using the approved standard method.
Simple, fast, and sensitive colorimetric probe developed for determination of hyoscine butylbromide in pharmaceutical formulations.
氢溴酸东莨菪碱作为一种抗痉挛药物，用于治疗消化性溃疡、胃炎和各种以痉挛为特征的胃肠道紊乱。它还用于缓解胆管和泌尿道痉挛，并治疗痛经。
本研究描述了将银纳米粒子（Ag NPs）用作比色探针，用于快速、选择性和简单地测定氢溴酸东莨菪碱。
该方法基于 Ag NPs 与所述药物相互作用引起的聚集。这种相互作用导致颜色从黄色变为无色，在 405nm 处测量。
该方法的线性浓度范围为 0.10-50.0μg/mL，相关方程为（y=0.0132x+0.3174），相关系数为 0.9981，定量限为 0.091μg/mL。对该方法的分析性能进行了全面研究，结果令人满意。该方法具有很高的准确性和精密度，用于鉴定药物片剂样品中的药物，回收率在 96.20%至 98.10%之间。
由于所描述的方法没有涉及关键的反应条件或溶剂萃取，因此它具有简单的特点。结果与使用批准的标准方法获得的结果非常一致。
开发了一种简单、快速和灵敏的比色探针，用于测定药物制剂中的氢溴酸东莨菪碱。
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