Teixeira Thiago A, Iori Ivan, Andrade Gustavo, Saldiva Paulo H N, Drevet Joël R, Costa Elaine M F, Hallak Jorge
Androscience-Science and Innovation Center in Andrology and High-Complex Clinical and Research Andrology Laboratory, São Paulo, Brazil.
Division of Urology, Hospital das Clinicas, University of São Paulo Medical School, São Paulo, Brazil.
Front Reprod Health. 2022 Feb 17;4:820451. doi: 10.3389/frph.2022.820451. eCollection 2022.
Marijuana is one of the most consumed drugs worldwide. There is increasing evidence of an association between marijuana and male infertility. This study intends to assess the repercussion of marijuana smoking and other habits (sedentary lifestyle, alcohol, and tobacco use) in the testicular function of infertile men seeking andrological evaluation. A retrospective study was performed using medical records data of men aged 18-59 years from 2009 to 2017. Complete semen analyses, sperm functional tests, SHBG, and hormonal levels, testosterone-to-estradiol ratio (T/E), and testis volume were evaluated. Exclusion criteria included cryptorchidism, infertility caused by genetic or infectious diseases, and cancer. A multiple linear regression analysis was performed to investigate which habit could predict certain parameters using the software SPSS 23.0 ( < 0.05). In a sample of 153 men, semen parameters, testosterone levels, and testis volume were not significantly influenced. Marijuana use had the broader hormonal changes since it influences estradiol ( = 0.000; = -11.616), prolactin ( = 0.000; = 3.211), SHBG levels ( = 0.017; = 7.489), and T/E ( = 0.004; = 14.030). Sedentary lifestyle ( = 0.028; = 1.279) and tobacco smoking ( = 0.031; = -2.401) influenced the prolactin levels. Marijuana is associated with hormonal imbalance in this infertile cohort by lowering estradiol levels and inhibiting aromatase function.
大麻是全球消费最为广泛的毒品之一。越来越多的证据表明大麻与男性不育之间存在关联。本研究旨在评估吸食大麻及其他习惯（久坐不动的生活方式、饮酒和吸烟）对寻求男科评估的不育男性睾丸功能的影响。利用2009年至2017年18 - 59岁男性的医疗记录数据进行了一项回顾性研究。评估了完整的精液分析、精子功能测试、性激素结合球蛋白（SHBG）、激素水平、睾酮与雌二醇比值（T/E）以及睾丸体积。排除标准包括隐睾症、由遗传或传染病导致的不育以及癌症。使用SPSS 23.0软件进行多元线性回归分析，以研究哪种习惯能够预测某些参数（<0.05）。在153名男性样本中，精液参数、睾酮水平和睾丸体积未受到显著影响。吸食大麻导致的激素变化范围更广，因为它会影响雌二醇（=0.000；=-11.616）、催乳素（=0.000；=3.211）、SHBG水平（=0.017；=7.489）以及T/E（=0.004；=1 4.030）。久坐不动的生活方式（=0.028；=1.279）和吸烟（=0.031；=-2.401）会影响催乳素水平。在这个不育队列中，大麻通过降低雌二醇水平和抑制芳香化酶功能与激素失衡有关。
