Kamilos Márcia Farina, Costa Ana Paula Ferreira, Sarmento Ayane Cristine Alves, Eleutério José, Gonçalves Ana Katherine
Department of Gynecology, Hospital Heliópolis, São Paulo, Brazil.
Postgraduate Program in Health Sciences, Federal University of Rio Grande Do Norte (UFRN), Natal, Brazil.
Front Reprod Health. 2021 Dec 7;3:779421. doi: 10.3389/frph.2021.779421. eCollection 2021.
The genitourinary syndrome in menopause can occur at different stages of life, with different causes or triggering factors, such as prolonged use of antiestrogens, chemotherapy, radiotherapy, and extensive vaginal surgeries, which can alter vascularization, hydration, collagen quality, and tissue elasticity. Despite hormonal therapy being considered the best evidenced treatment for genitourinary syndrome of menopause (GSM), there are limitations concerning the latter. Thus, alternative, complementary, or even substitutive treatments have emerged, such as energy use, promoting thermal tissue stimulation to improve tropism. Due to its practicality and feasibility, the micro ablative fractional radiofrequency (MAFRF) has gained space among these energies. It uses high-frequency electromagnetic waves and promotes thermal micro points in the superficial and deep dermis. The safety of these energies limits thermal action laterality and depth. Laterally, it is essential for an adequate regenerative effect without scarring marks or sequelae; the appropriate depth is important for stimulating the obligatory tissue repair response with the production and reorganization of collagen, elastic fibers, increased vascularization and hydration, and the consequent improvement in tropism. In gynecology, the MAFRF is used with therapeutic indication and functional improvement; it is applied to the entire length of the vaginal walls, the vulvar vestibule, urethral meatus, labia minora, clitoris prepuce, labia majora, perineum, and perianal region. The MAFRF has been proved to be an effective and safe treatment for GSM, with long-lasting effects, significantly reducing symptoms and improving vaginal tropism. This review aims to analyze the MAFRF as a non-hormonal therapeutic option for GSM.
更年期泌尿生殖综合征可发生于生命的不同阶段,有不同的病因或触发因素,如长期使用抗雌激素药物、化疗、放疗以及广泛的阴道手术,这些都可能改变血管化、水合作用、胶原蛋白质量和组织弹性。尽管激素疗法被认为是治疗更年期泌尿生殖综合征(GSM)最有证据支持的疗法,但后者存在局限性。因此,出现了替代、补充甚至替代疗法,如能量利用,促进热组织刺激以改善向性。由于其实用性和可行性,微剥脱分次射频(MAFRF)在这些能量中占据了一席之地。它使用高频电磁波,在浅表和深层真皮中产生热微点。这些能量的安全性限制了热作用的侧向性和深度。从侧向来看,对于产生无瘢痕或后遗症的充分再生效果至关重要;合适的深度对于刺激必要的组织修复反应很重要,包括胶原蛋白、弹性纤维的产生和重组、血管化和水合作用增加,以及随之而来的向性改善。在妇科中,MAFRF用于治疗指征和功能改善;它应用于阴道壁全长、外阴前庭、尿道口、小阴唇、阴蒂包皮、大阴唇、会阴和肛周区域。MAFRF已被证明是一种治疗GSM的有效且安全的疗法,具有持久效果,能显著减轻症状并改善阴道向性。本综述旨在分析MAFRF作为GSM的非激素治疗选择。