Sperschneider H, Stein G, Michael R, Both R, Keil E, Kunath K, Wessel G, Lohr I
Z Urol Nephrol. 1987 Apr;80(4):217-27.
The role of PTH as possible uraemic toxin within the scope of disturbances of the central nervous system (progressive dialysis encephalopathy, PDE) was investigated in 88 patients undergoing haemodialysis. A radioimmunoassay covering the C-terminal PTH fragment was used. Patients undergoing haemodialysis with a PDE showed the highest values with 2,015.4 +/- 457.9 pg/ml, and also in the preclinical stage of a PDE the PTH values with 1,845.7 +/- 663.1 pg/ml lay significantly above those ones of the patients undergoing haemodialysis without PDE (794.8 +/- 364.7 pg/ml). The findings speak for the importance of PTH in the development of complications of the central nervous system within the scope of the uraemia syndrome.
在88例接受血液透析的患者中，研究了甲状旁腺激素（PTH）作为中枢神经系统紊乱（进行性透析脑病，PDE）范围内可能的尿毒症毒素的作用。使用了一种覆盖C末端PTH片段的放射免疫测定法。患有PDE的血液透析患者的值最高，为2015.4±457.9 pg/ml，并且在PDE的临床前期，PTH值为1845.7±663.1 pg/ml，也显著高于未患PDE的血液透析患者（794.8±364.7 pg/ml）。这些发现表明PTH在尿毒症综合征范围内中枢神经系统并发症的发生中具有重要作用。
