Yang Yinyu, Wu Yibei, Zhang Wen, Cao Qing, Zhang Haibo, Zhang Hao, Dong Wei
Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Department of Infectious Disease, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Front Cardiovasc Med. 2022 Oct 11;9:1001780. doi: 10.3389/fcvm.2022.1001780. eCollection 2022.
To analyze the clinical characteristics and prognostic factors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant infections in children with congenital heart disease (CHD).
A retrospective analysis was performed on SARS-CoV-2 Omicron-infected children with CHD who were admitted to Shanghai Children's Medical Center from April 1, 2022 to May 31, 2022. The clinical, laboratory and imaging data, and the nucleic acid conversion time of the children in this group were collected and analyzed.
Thirteen patients were included in this study and had an average age of 1.1 (0.16-14) years. Among the patients, 3 patients were preoperatively treated, and 10 were postoperatively treated. According to the severity of the disease, 1 patient was diagnosed with the moderate type, and the remaining 12 patients were diagnosed with the mild type. The clinical symptoms were mostly associated with upper respiratory tract infections, including 13 with fever (100%), 8 with cough (61.8%), 5 with sputum production (38.5%), 1 of shortness of breath (7.7%), etc. All patients were successfully discharged from the hospital, with 16.4 ± 2.9 days needed to obtain cycle threshold (CT) values ≥35 in nucleic acid testing and 17.5 ± 3.6 days of hospitalization.
For vulnerable patients such as children with CHD, SARS-CoV-2 Omicron variant infections mostly present with mild upper respiratory tract symptoms with negative or mildly changed chest imaging. Through appropriate treatment of the underlying disease in the quarantine ward, patients might obtain good outcomes, even after long periods of hospitalization.
分析先天性心脏病（CHD）患儿感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）奥密克戎变异株的临床特征及预后因素。
对2022年4月1日至2022年5月31日收治于上海儿童医学中心的感染SARS-CoV-2奥密克戎变异株的CHD患儿进行回顾性分析。收集并分析该组患儿的临床、实验室及影像学资料，以及核酸转阴时间。
本研究共纳入13例患者，平均年龄1.1（0.16 - 14）岁。其中3例为术前治疗患者，10例为术后治疗患者。根据疾病严重程度，1例诊断为中型，其余12例诊断为轻型。临床症状多与上呼吸道感染有关，包括发热13例（100%）、咳嗽8例（61.8%）、咳痰5例（38.5%）、气促1例（7.7%）等。所有患者均顺利出院，核酸检测获得循环阈值（CT）值≥35所需时间为16.4±2.9天，住院时间为17.5±3.6天。
对于CHD患儿等易感患者，SARS-CoV-2奥密克戎变异株感染多表现为轻度上呼吸道症状，胸部影像学检查阴性或轻度改变。通过在隔离病房对基础疾病进行适当治疗，患者即使经过较长时间住院，也可能获得良好预后。
