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作者信息

Horner David, Enevoldsen Juliane, Stokholm Jakob, Bønnelykke Klaus, Chawes Bo

机构信息

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Københavns Universitetshospital - Herlev og Gentofte Hospital.

Sektionen Mikrobiologi og Fermentering, Institut for Fødevarevidenskab, Københavns Universitet.

出版信息

Ugeskr Laeger. 2022 Oct 17;184(42).

PMID:36305261

Abstract

The incidence of asthma and obesity in childhood has been increasing for decades. Obesity-related asthma is thought to be influenced by changes in the lungs’ mechanical properties and airway remodeling due to systemic inflammation and metabolic dysregulation. It is characterized by Th1-inflammation and impaired lung function, which responds poorly to conventional asthma treatment with inhaled β2-agonists and corticosteroids. The purpose of this review is to increase awareness of obesity-related asthma in children and adolescents and highlight possible underlying mechanisms and interventions.

摘要

几十年来，儿童哮喘和肥胖的发病率一直在上升。与肥胖相关的哮喘被认为受到全身炎症和代谢失调导致的肺部机械性能变化和气道重塑的影响。其特征为Th1炎症和肺功能受损，对吸入β2激动剂和皮质类固醇的传统哮喘治疗反应不佳。本综述的目的是提高对儿童和青少年肥胖相关哮喘的认识，并强调可能的潜在机制和干预措施。