Retinal Disorders and Ophthalmic Genetics Division, Stein Eye Institute, University of California Los Angeles, Los Angeles, California, United States.
Doheny Eye Institute, Department of Ophthalmology, University of California, Los Angeles, Los Angeles, California, United States.
Invest Ophthalmol Vis Sci. 2022 Oct 3;63(11):24. doi: 10.1167/iovs.63.11.24.
To determine if increasing drusen height correlates with predictive optical coherence tomography (OCT) biomarkers of atrophy.
Retrospective cross-sectional study that enrolled patients with drusen associated with intermediate AMD. Macular drusen were classified as small, intermediate, large, or very large based on OCT quartile measurement of height. Drusen diameter was also tabulated. The presence and localization of the OCT biomarkers of atrophy were assessed: disruption of the external limiting membrane and ellipsoid zone, intraretinal hyper-reflective foci, RPE disruption, choroidal hypertransmission, and presence of hyporeflective cores. Predictive OCT biomarkers of atrophy were correlated with drusen height.
A total of 155 eyes from 104 patients met the inclusion and exclusion criteria. The mean age was 75.7 ± 8.7 years, and patients were predominantly female (74.0%). The mean visual acuity was logMAR 0.2 ± 0.2 (Snellen equivalent 20/32). The average drusen height was 134.6 ± 107.5 µm and the greatest horizontal diameter was 970.7 ± 867.4 µm. Disruption of the external limiting membrane and ellipsoid zone, RPE thickening or thinning, intraretinal hyper-reflective foci, choroidal hypertransmission, and presence of hyporeflective cores (P < 0.05) were more common in eyes with large drusen and very large drusen versus small or intermediate drusen. All biomarkers were positively correlated with drusen height. OCT biomarkers of atrophy were predominantly located at the apex of the drusen.
Predictive OCT biomarkers of atrophy, specifically signs of RPE breakdown and disruption, occur more commonly in large or very large drusen, especially in drusen with greater height and separation of the RPE from the underlying choroid.
确定玻璃膜疣高度的增加是否与萎缩的预测性光学相干断层扫描（OCT）生物标志物相关。
回顾性横断面研究纳入了与中间型年龄相关性黄斑变性相关的玻璃膜疣患者。根据 OCT 高度四分位数测量，将黄斑玻璃膜疣分为小、中、大或非常大。还列出了玻璃膜疣的直径。评估了萎缩的 OCT 生物标志物的存在和定位：外节膜和椭圆体带的破坏、视网膜内高反射灶、RPE 破坏、脉络膜高透过性和低反射核的存在。预测性 OCT 生物标志物与玻璃膜疣高度相关。
共有 104 例患者的 155 只眼符合纳入和排除标准。平均年龄为 75.7±8.7 岁，患者主要为女性（74.0%）。平均视力为 logMAR 0.2±0.2（Snellen 等效 20/32）。平均玻璃膜疣高度为 134.6±107.5μm，最大水平直径为 970.7±867.4μm。外节膜和椭圆体带的破坏、RPE 增厚或变薄、视网膜内高反射灶、脉络膜高透过性和低反射核的存在（P<0.05）在大玻璃膜疣和超大玻璃膜疣眼中比小玻璃膜疣或中玻璃膜疣更为常见。所有生物标志物均与玻璃膜疣高度呈正相关。萎缩的 OCT 生物标志物主要位于玻璃膜疣的顶点。
预测性 OCT 生物标志物的萎缩，特别是 RPE 破裂和破坏的迹象，在大或超大玻璃膜疣中更为常见，尤其是在高度和 RPE 与下方脉络膜分离更大的玻璃膜疣中更为常见。
