空鼻综合征患者的睡眠障碍

Sleep impairment in patients with empty nose syndrome.

作者信息

Huang C-C, Lee C-C, Wu P-W, Chuang C-C, Lee Y-S, Chang P-H, Huang C-C, Fu C-H, Lee T-J

机构信息

Division of Rhinology, Department of Otolaryngology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taiwan; School of Medicine, Chang Gung University, Taoyuan, Taiwan.

School of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou and Chang Gung University, Taiwan; Department of Biomedical Engineering, National Taiwan University, Taipei, Taiwan.

出版信息

Rhinology. 2023 Feb 1;61(1):47-53. doi: 10.4193/Rhin22.117.

DOI:10.4193/Rhin22.117

PMID:36306524

Abstract

BACKGROUND

Empty nose syndrome (ENS) is characterized by paradoxical nasal obstruction that usually occurs after turbinate surgery. Patients with ENS may also experience significant psychiatric symptoms and sleep dysfunction, which negatively affect the quality of life of affected subjects. This study aimed to evaluate sleep impairment and sleepiness in patients with ENS.

METHODS

Patients with ENS and control participants were recruited prospectively. The Sino-Nasal Outcome Test-25 (SNOT-25), Empty Nose Syndrome 6-item Questionnaire (ENS6Q), Epworth Sleepiness Scale (EpSS), and modified sleep quality index (MSQI) were used to evaluate the participants before and after nasal surgery.

RESULTS

Forty-eight patients with ENS and forty-eight age- and sex-matched control subjects were enrolled. The SNOT-25, ENS6Q, EpSS, and MSQI scores in the ENS group were all significantly higher than those in the control group before and after surgery. After surgery, ENS patients all exhibited significant improvements in SNOT-25, ENS6Q, EpSS, and MSQI scores. Regression analysis revealed that SNOT-25 score was a significant predictor of EpSS and MSQI in preoperative evaluations. ENS patients experiencing daytime sleepiness suffered from significantly more "dryness of nose" and "suffocation" than those not experiencing daytime sleepiness.

CONCLUSIONS

Patients with ENS experienced significantly impaired sleep quality and sleepiness. Nasal reconstruction surgery improved the sleep quality of ENS patients. The severity of sleep dysfunction is associated with the severity of ENS symptoms. Recognizing individuals with significant sleep impairment and sleepiness and providing appropriate management are critical issues for ENS patients.

摘要

背景

空鼻综合征（ENS）的特征是通常在鼻甲手术后出现的矛盾性鼻阻塞。ENS患者还可能出现明显的精神症状和睡眠功能障碍，这对受影响患者的生活质量产生负面影响。本研究旨在评估ENS患者的睡眠障碍和嗜睡情况。

方法

前瞻性招募ENS患者和对照参与者。使用鼻-鼻窦结局测试-25（SNOT-25）、空鼻综合征6项问卷（ENS6Q）、爱泼沃斯嗜睡量表（EpSS）和改良睡眠质量指数（MSQI）在鼻手术前后评估参与者。

结果

招募了48例ENS患者和48例年龄及性别匹配的对照受试者。ENS组的SNOT-25、ENS6Q、EpSS和MSQI评分在手术前后均显著高于对照组。手术后，ENS患者的SNOT-25、ENS6Q、EpSS和MSQI评分均有显著改善。回归分析显示，在术前评估中，SNOT-25评分是EpSS和MSQI的显著预测指标。经历白天嗜睡的ENS患者比未经历白天嗜睡的患者有更多的“鼻干”和“窒息”症状。