Innovative Institute of Animal Healthy Breeding, College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China; Department of Pharmacology, College of Basic Medical Science, Jilin University, Changchun, 130021, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China.
Innovative Institute of Animal Healthy Breeding, College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China.
Arch Biochem Biophys. 2022 Nov 30;731:109448. doi: 10.1016/j.abb.2022.109448. Epub 2022 Oct 25.
Alzheimer's disease (AD), a common neurodegenerative disease, is characterised by the deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles. An increasing number of studies have demonstrated that Aβ causes neuronal damage and mitochondrial dysfunction. Herein, we evaluated the neuroprotective effect of sodium butyrate (NaB) against Aβ induced neurotoxicity in PC12 cells. The results revealed that 3 mM of NaB promoted the expression of angiotensin-converting enzyme and brain-derived neurotrophic factor, which exert a neuroprotective effect by activating G protein-coupled receptors. Moreover, NaB could significantly improve mitochondrial dysfunction caused by Aβ. In conclusion, NaB protected PC12 cells from Aβ-induced cell damage, highlighting the potential of NaB in AD treatment.
阿尔茨海默病（AD）是一种常见的神经退行性疾病，其特征是淀粉样蛋白-β（Aβ）斑块和神经纤维缠结的沉积。越来越多的研究表明，Aβ 会导致神经元损伤和线粒体功能障碍。在此，我们评估了丁酸钠（NaB）对 PC12 细胞中 Aβ 诱导的神经毒性的神经保护作用。结果表明，3 mM 的 NaB 可促进血管紧张素转换酶和脑源性神经营养因子的表达，通过激活 G 蛋白偶联受体发挥神经保护作用。此外，NaB 可显著改善 Aβ 引起的线粒体功能障碍。综上所述，NaB 可保护 PC12 细胞免受 Aβ 诱导的细胞损伤，凸显了 NaB 在 AD 治疗中的潜力。
Arch Biochem Biophys. 2022-11-30
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