Department of Neurology, Qingdao Central Hospital, Qingdao, Shandong, China.
Department of Interventional Radiology, Jinan Military General Hospital, Shifan Road 25, Tianqiao District, Jinan, 250000, Shandong, China.
J Mol Neurosci. 2018 Dec;66(4):512-523. doi: 10.1007/s12031-018-1175-2. Epub 2018 Oct 22.
Alzheimer's disease (AD) is the most common neurodegenerative disorder and is characterized by the deposition of β-Amyloid (Aβ) plaques which contribute to its pathology. The present study was aimed at exploring the protective effects of euxanthone against Aβ-induced neurotoxicity both in vivo and in vitro. We found that euxanthone significantly attenuated Aβ-induced memory and spatial learning dysfunction and also significantly reversed Aβ-induced neuronal apoptosis and autophagy in the hippocampal region. Euxanthone also protected the neuroblastic PC12 cells against Aβ-induced oxidative stress and apoptosis by inducing autophagy. In conclusion, euxanthone exerts its neuroprotective effect against Aβ by inducing autophagy, indicating its potential therapeutic role in AD.
阿尔茨海默病（AD）是最常见的神经退行性疾病，其特征是β-淀粉样蛋白（Aβ）斑块的沉积，这有助于其发病机制。本研究旨在探讨柚皮素对体内和体外 Aβ诱导的神经毒性的保护作用。我们发现柚皮素可显著减轻 Aβ引起的记忆和空间学习功能障碍，并显著逆转 Aβ诱导的海马区神经元凋亡和自噬。柚皮素还通过诱导自噬来保护神经母细胞瘤 PC12 细胞免受 Aβ诱导的氧化应激和凋亡。总之，柚皮素通过诱导自噬发挥其对 Aβ的神经保护作用，表明其在 AD 中的潜在治疗作用。
