Northeast Ohio Medical University, USA.
Department of Surgery, USA; Case Western Reserve University School of Medcine, Cleveland, OH, USA.
Am J Surg. 2023 Mar;225(3):477-480. doi: 10.1016/j.amjsurg.2022.10.028. Epub 2022 Oct 18.
Hyperparathyroid crisis (HPTC) is a potentially lethal condition characterized by severe symptomatic hypercalcemia with calcium levels ≥14 mg/dl. We sought to determine the rate of HPTC and how it differs from hyperparathyroidism (HPT) without crisis (HPTWC).
A retrospective review of patients with surgically treated HPT from 1990 to 2022 was completed.
HPTC occurred in 18 (2.4%) of 783 with primary HPT. Patients with HPTC had higher preoperative calcium and parathyroid hormone levels, lower postoperative calcium levels, larger gland weights and higher rates of ectopic glands, carcinoma, recurrence and mortality compared to patients with HPTWC (all p < 0.05).
HPTC is a rare condition manifested by severe HPT that is associated with a higher rate of recurrence and mortality compared to HPTWC. HPTC is associated with larger parathyroid glands that are more often ectopic and malignant.
甲状旁腺危象（HPTC）是一种潜在致命的疾病，其特征是严重的症状性高钙血症，钙水平≥14mg/dl。我们旨在确定 HPTC 的发生率以及它与无危象的甲状旁腺功能亢进症（HPTWC）有何不同。
对 1990 年至 2022 年接受手术治疗的 HPT 患者进行回顾性分析。
783 例原发性 HPT 患者中有 18 例（2.4%）发生 HPTC。与 HPTWC 患者相比，HPTC 患者术前血钙和甲状旁腺激素水平更高，术后血钙水平更低，腺体重量更大，异位腺体、癌、复发和死亡率更高（均 p<0.05）。
HPTC 是一种罕见的疾病，表现为严重的 HPT，与 HPTWC 相比，复发和死亡率更高。HPTC 与更大的甲状旁腺腺体有关，这些腺体更常为异位和恶性。
