Mio Kento, Togo-Ohno Marina, Tadenuma Natsuki, Ogawa Reina, Yamanaka Chiemi, Aoe Seiichiro
Graduate School of Studies in Human Culture, Otsuma Women's University, Tokyo, Japan.
Research and Development Department, Hakubaku co., Ltd., Yamanashi, Japan.
Biosci Biotechnol Biochem. 2022 Dec 21;87(1):99-107. doi: 10.1093/bbb/zbac171.
Diet with barley may suppress the glycemic response after consuming the next meal ("second meal effect"). This study aimed to investigate the second meal effect and its mechanism. Mice were given a single dose of β-glucan or arabinoxylan, the primary sources of soluble fiber in barley. A single dose of β-glucan or arabinoxylan extract, followed 6 h later by a 20% glucose solution (second meal), suppressed blood glucose elevation. Arabinoxylan and β-glucan increased the levels of short-chain fatty acids (SCFAs) in the ileum and cecum, respectively. Total GLP-1 secretion in the blood increased with β-glucan and showed an increasing trend with arabinoxylan. These results suggest barley β-glucan and arabinoxylan are fermented in the intestinal tract to generate SCFAs, which may induce GLP-1 secretion and control blood glucose levels during the second meal.
食用大麦饮食可能会抑制下一餐进食后的血糖反应（“第二餐效应”）。本研究旨在探究第二餐效应及其机制。给小鼠单次服用β-葡聚糖或阿拉伯木聚糖，这是大麦中可溶性纤维的主要来源。单次服用β-葡聚糖或阿拉伯木聚糖提取物，6小时后再给予20%葡萄糖溶液（第二餐），可抑制血糖升高。阿拉伯木聚糖和β-葡聚糖分别增加了回肠和盲肠中短链脂肪酸（SCFAs）的水平。血液中总胰高血糖素样肽-1（GLP-1）分泌量随β-葡聚糖增加，并随阿拉伯木聚糖呈上升趋势。这些结果表明，大麦β-葡聚糖和阿拉伯木聚糖在肠道中发酵产生SCFAs，这可能会诱导GLP-1分泌，并在第二餐期间控制血糖水平。
