COVID-19 孕妇 CRP/白蛋白比值水平与预后的关系。

The Relationship of CRP/Albumin ratio level and prognosis in pregnant COVID-19 patients.

机构信息

Department of Anesthesia and Reanimation, Adiyaman Training and Research Hospital, Adiyaman, Turkey.

Department of Anesthesiology and Reanimation, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey.

出版信息

Niger J Clin Pract. 2022 Oct;25(10):1745-1750. doi: 10.4103/njcp.njcp_244_22.

DOI:10.4103/njcp.njcp_244_22

PMID:36308249

Abstract

BACKGROUND

The C-reactive protein (CRP)/albumin ratio (CAR) is one of the new tools to assess the severity of inflammation. It is used to determine clinical severity and prognosis in many diseases.

AIM

The present study aimed to investigate the relationship between C-reactive protein (CRP)/albumin ratio (CAR) and prognosis in pregnant patients with more severe COVID-19 infection. Retrospective study.

PATIENTS AND METHODS

The study was conducted in a retrospective manner by scanning the files of pregnant patients who had a positive polymerase chain reaction test result and were hospitalized in Adıyaman Training and Research Hospital. The patients were divided into two groups: patients who were admitted to the intensive care unit and patients who were not admitted. CRP/albumin ratio (CAR) levels were compared between these two groups. The cut-off value was determined in the prediction of intensive-care admission and poor prognosis.

RESULTS

117 patient files were reviewed. 13 patients were followed up with intensive care, whereas 104 patients completed their treatment in the service. The CAR levels of the patients admitted to intensive care were significantly higher (P < 0.01). In the estimation of intensive-care admission, the CAR level was determined to be 0.970 in the area under the curve with 100% sensitivity and 86.5% specificity in the receiver operating characteristic (ROC) curve. The cut-off CAR level was calculated as 1.8.

CONCLUSION

CAR is a valuable biomarker for predicting prognosis, as well as follow-ups of pregnant COVID-19 patients.

摘要

背景

C 反应蛋白（CRP）/白蛋白比值（CAR）是评估炎症严重程度的新工具之一。它被用于确定许多疾病的临床严重程度和预后。

目的

本研究旨在探讨 CRP/白蛋白比值（CAR）与重症 COVID-19 感染孕妇预后的关系。回顾性研究。

患者和方法

通过扫描阿迪亚曼培训和研究医院住院的聚合酶链反应检测结果呈阳性的孕妇的档案，以回顾性方式进行研究。将患者分为两组：入住重症监护病房的患者和未入住重症监护病房的患者。比较两组之间的 CRP/白蛋白比值（CAR）水平。确定临界值以预测入住重症监护病房和预后不良。

结果

共回顾了 117 份患者档案。13 名患者入住重症监护病房，104 名患者在该科完成治疗。入住重症监护病房的患者的 CAR 水平显著升高（P<0.01）。在入住重症监护病房的估计中，CAR 水平在曲线下面积为 0.970，在接收者操作特征（ROC）曲线上具有 100%的敏感性和 86.5%的特异性。计算出的临界 CAR 水平为 1.8。