Department of Gynecological Oncology, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China.
Asian Pac J Cancer Prev. 2022 Oct 1;23(10):3393-3404. doi: 10.31557/APJCP.2022.23.10.3393.
This study was to determine the prevalence of HPV in non-vaccinated women from East China, and the association between prestored smartphone monitored physical activity and the risk of human papillomaviruses (HPV) infection and cervical cancer.
We retrospectively reviewed medical records of unvaccinated women received first-time cervical HPV screening in the Affiliated Cancer Hospital of University of Chinese Academy of Sciences between March 2018 and December 2019. HPV genotyping was examined by the GenoArray. Physical activity defined by any movements at speeds of 0.5-2 m/s was obtained from smartphones. We collected prestored physical activity data for 6 months prior to the HPV screening. Logistic regression models were applied to determine the association between physical activity and the risk of HPV infection and cervical cancer.
A total of 11,730 women were initially included. Women with cervical cancer had significantly higher prevalence of infection with any high-risk (HR) HPV, or with individual HPV16, 18, 31, 33, 45, 52 and 58. Among them, 896 controls and 289 cervical cancer women had information of smartphone monitored physical activity. Multivariate logistic regression analysis showed that more daily physical activity time (or distance) was a protective factor for infection with any HR HPV, or infection with HPV16, but not other individual HPVs. Increased age, less physical activity time (or distance), and infection with any HR HPV (16, 18, 31, 52 and 58) were associated with a significantly increased risk of cervical cancer. In contrast, obesity was not associated with risk of HPV infection and cervical cancer.
The high prevalence of HPV infection in unvaccinated women highlights the importance of prevention. More daily physical activity time (or distance) may help to reduce the risk of HPV infection and cervical cancer. Smartphone monitoring is an effective tool for recording physical activity.
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本研究旨在确定华东地区未接种疫苗女性 HPV 的流行率，以及预先存储的智能手机监测到的身体活动与人类乳头瘤病毒（HPV）感染和宫颈癌风险之间的关联。
方法：我们回顾性分析了 2018 年 3 月至 2019 年 12 月在中国科学院大学附属肿瘤医院接受首次宫颈 HPV 筛查的未接种疫苗女性的病历。HPV 基因分型采用 GenoArray 进行检测。智能手机获取 0.5-2 m/s 速度下的任何运动定义为身体活动。我们收集了 HPV 筛查前 6 个月的预先存储的身体活动数据。应用逻辑回归模型确定身体活动与 HPV 感染和宫颈癌风险之间的关联。
结果：共纳入 11730 名女性。宫颈癌患者感染任何高危（HR）HPV 或 HPV16、18、31、33、45、52 和 58 的个体的感染率显著较高。其中，896 名对照和 289 名宫颈癌患者有智能手机监测身体活动的信息。多变量逻辑回归分析表明，每天更多的身体活动时间（或距离）是感染任何 HR HPV 或 HPV16 的保护因素，但不是其他个体 HPV 的保护因素。年龄增长、身体活动时间（或距离）减少、感染任何 HR HPV（16、18、31、52 和 58）与宫颈癌风险显著增加相关。相比之下，肥胖与 HPV 感染和宫颈癌风险无关。
结论：未接种疫苗女性 HPV 感染率高，强调了预防的重要性。每天更多的身体活动时间（或距离）可能有助于降低 HPV 感染和宫颈癌的风险。智能手机监测是记录身体活动的有效工具。
