Chen Ruohua, Yang Xinlan, Yu Xiaofeng, Zhou Xiang, Ng Yee Ling, Chen Yumei, Li Lianghua, Zhou Yun, Huang Gang, Liu Jianjun
Department of Nuclear Medicine, School of Medicine, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, China.
Central Research Institute, United Imaging Healthcare Group Co, Ltd, Shanghai, China.
Eur J Nucl Med Mol Imaging. 2023 Feb;50(3):661-666. doi: 10.1007/s00259-022-06004-3. Epub 2022 Oct 29.
[ Ga]Ga-FAPI-04 PET/CT has been widely used in oncology patients. The patients need to lie still for 20-30 min during scan after waiting for 60 min post-tracer injection in traditional [ Ga]Ga-FAPI-04 PET/CT scan. This is difficult for some patients who are intolerant to prolonged horizontal positioning and waiting time. Therefore, we evaluated the diagnostic value of the images obtained in ultra-early and fast scan (5-min p.i., 30-s acquisition time) by the total-body [ Ga]Ga-FAPI-04 PET/CT and to investigate whether they could meet the requirements of clinical diagnosis.
Total-body [ Ga]Ga-FAPI-04 PET/CT was conducted in 12 patients at the Renji Hospital. Patients underwent PET with two acquisitions: 5-min p.i. and 30-s acquisition time (ultra-early and fast imaging) and 60-min p.i. and 300-s acquisition time (traditional imaging). Mean [ Ga]Ga-FAPI-04 injection dose was 1.85 MBq/kg.
Forty-four lesions were detected in 12 patients on traditional imaging. All the 44 lesions on conventional imaging could also detected by ultra-early and fast imaging. For all the 12 patients, the tumor stage did not change, as same lesions were visible for every case in both images. There was no statistically significant difference in SUVmax of lesions between ultra-early and fast imaging and traditional imaging (12.5 ± 8.7 vs 13.7 ± 8.5, P = 0.528). Background bloodpool (4.0 ± 0.6 vs 0.9 ± 0.2, P < 0.001)and liver (2.5 ± 0.7 vs 1.0 ± 0.5, P < 0.001)at traditional imaging showed a significant decrease in SUVmean compared to ultra-early and fast imaging.
Ultra-early and fast imaging versus traditional [ Ga]Ga-FAPI-04 imaging resulted in equivalent tumor detection and lesion uptake. Ultra-early and fast total-body [ Ga]Ga-FAPI-04 PET/CT scan could meet clinical diagnostic requirements for patients with poor tolerant to prolonged horizontal positioning and waiting time.
[镓]Ga-FAPI-04 PET/CT已广泛应用于肿瘤患者。在传统的[镓]Ga-FAPI-04 PET/CT扫描中，患者在注射示踪剂后等待60分钟，扫描期间需要静卧20 - 30分钟。这对于一些无法耐受长时间水平卧位和等待时间的患者来说较为困难。因此，我们评估了全身[镓]Ga-FAPI-04 PET/CT在超早期和快速扫描（注射后5分钟，采集时间30秒）所获得图像的诊断价值，并研究其是否能满足临床诊断需求。
在仁济医院对12例患者进行了全身[镓]Ga-FAPI-04 PET/CT检查。患者进行了两次PET采集：注射后5分钟、采集时间30秒（超早期和快速成像）以及注射后60分钟、采集时间300秒（传统成像）。[镓]Ga-FAPI-04的平均注射剂量为1.85 MBq/kg。
在传统成像中，12例患者共检测到44个病灶。超早期和快速成像也能检测到所有这44个病灶。对于所有12例患者，肿瘤分期未发生变化，因为两种图像中每个病例的可见病灶相同。超早期和快速成像与传统成像之间病灶的SUVmax无统计学显著差异（12.5±8.7 vs 13.7±8.5，P = 0.528）。与超早期和快速成像相比，传统成像时的背景血池（4.0±0.6 vs 0.9±0.2，P < 0.001）和肝脏（2.5±0.7 vs 1.0±0.5，P <
