习惯性补充鱼油与慢性阻塞性肺疾病发病的关系：一项前瞻性队列研究的数据。

Habitual fish oil supplementation and incident chronic obstructive pulmonary disease: Data from a prospective cohort study.

机构信息

Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.

出版信息

Clin Nutr. 2022 Dec;41(12):2651-2658. doi: 10.1016/j.clnu.2022.10.002. Epub 2022 Oct 8.

DOI:10.1016/j.clnu.2022.10.002

PMID:36308984

Abstract

BACKGROUND

Fish oil is one of the most popular supplements in the UK and other developed countries. However, the relationship between fish oil use and chronic obstructive pulmonary disease (COPD) is unclear.

OBJECTIVE

To prospectively examine the association of habitual fish oil supplementation with incident COPD risk and to evaluate potential effect modification by genetic predisposition.

METHODS

This study included 484,414 participants (mean and standard deviation [SD] age: 56.5 [8.1] years) from the UK Biobank who completed a touchscreen questionnaire on habitual fish oil supplement use between 2006 and 2010 and were followed up through 2018. Cox regression models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) with adjustment for sociodemographic and lifestyle behaviours, health conditions, and other potential confounding factors. A weighted genetic risk score (GRS) for COPD was derived from 112 validated single nucleotide polymorphisms.

RESULTS

During a median follow-up of 9.0 years, 8860 incident COPD events were recorded. A total of 31.4% (152,230) of the study participants reported habitual fish oil supplementation at baseline. Habitual fish oil supplementation was significantly associated with a lower risk of incident COPD (adjusted HR: 0.88; 95% CI: 0.84-0.93). The association with COPD did not differ by GRS strata (P for interaction = 0.880). The results from subgroup and sensitivity analyses supported the robustness of our findings.

CONCLUSIONS

Our findings suggest that habitual fish oil supplementation is associated with a lower risk of incident COPD, irrespective of genetic predisposition.

摘要

背景

鱼油是英国和其他发达国家最受欢迎的补充剂之一。然而，鱼油的使用与慢性阻塞性肺疾病（COPD）之间的关系尚不清楚。

目的

前瞻性研究习惯性鱼油补充与 COPD 发病风险的关系，并评估遗传易感性的潜在作用修饰。

方法

本研究纳入了来自英国生物库的 484414 名参与者（平均和标准差[SD]年龄：56.5[8.1]岁），他们在 2006 年至 2010 年期间通过触摸屏问卷完成了习惯性鱼油补充使用情况的调查，并随访至 2018 年。使用 Cox 回归模型来估计风险比（HRs）和 95%置信区间（95%CI），并调整了社会人口统计学和生活方式行为、健康状况和其他潜在混杂因素。COPD 的加权遗传风险评分（GRS）是从 112 个经过验证的单核苷酸多态性衍生而来的。

结果

在中位随访 9.0 年期间，记录了 8860 例新发 COPD 事件。研究参与者中有 31.4%（152230 人）在基线时报告了习惯性鱼油补充。习惯性鱼油补充与新发 COPD 的风险降低显著相关（调整后的 HR：0.88；95%CI：0.84-0.93）。与 COPD 的关联在 GRS 分层中没有差异（交互作用 P 值=0.880）。亚组和敏感性分析的结果支持了我们发现的稳健性。