Madias N E, Goorno W E, Herson S
Am J Kidney Dis. 1987 Sep;10(3):250-3. doi: 10.1016/s0272-6386(87)80182-8.
High plasma concentrations of epinephrine and norepinephrine have the potential for generating substantial hyperlactatemia by virtue of their metabolic and vasoconstrictor effects; both these influences affect lactate metabolism in the direction of overproduction and underutilization. Nonetheless, lactic acidosis is not a recognized presenting feature of pheochromocytoma. In this report, we describe a patient with pheochromocytoma in whom the endogenous outpouring of epinephrine and norepinephrine resulted in severe lactic acidosis that featured prominently in the clinical presentation. Pheochromocytoma should be listed among the clinical entities associated with or predisposing to lactic acidosis.
血浆中高浓度的肾上腺素和去甲肾上腺素因其代谢和血管收缩作用，有可能导致显著的高乳酸血症；这两种影响均朝着乳酸生成过多和利用不足的方向影响乳酸代谢。尽管如此，乳酸酸中毒并非嗜铬细胞瘤公认的临床表现。在本报告中，我们描述了一名患有嗜铬细胞瘤的患者，其体内肾上腺素和去甲肾上腺素的内源性分泌导致了严重的乳酸酸中毒，这在临床表现中尤为突出。嗜铬细胞瘤应被列入与乳酸酸中毒相关或易引发乳酸酸中毒的临床病症之中。
