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21三体综合征患儿是感染重症新型冠状病毒肺炎的高危群体：来自埃塞俄比亚亚的斯亚贝巴一家新型冠状病毒肺炎治疗单位的病例报告。

Children with trisomy 21 are a group at risk for severe COVID-19: Case reports from a COVID-19 treatment unit in Addis Ababa, Ethiopia.

作者信息

Alemayehu Tinsae, Buonsenso Danilo

机构信息

American Medical Center, Addis Ababa, Ethiopia.

St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.

出版信息

Front Pediatr. 2022 Oct 13;10:991142. doi: 10.3389/fped.2022.991142. eCollection 2022.

DOI:10.3389/fped.2022.991142
PMID:36313884
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9612718/
Abstract

Trisomy 21 (Down syndrome) is a chromosomal disorder associated with humoral and cellular immunologic impairments among other systemic manifestations. It occurs at a frequency of 1 in 750 live births. There are increasing reports of children with Down syndrome presenting signs of severe COVID-19. The literature from Africa on pediatric COVID-19 and risk stratification for severe disease is scant. A summary of the clinical features, complications, and treatment outcomes of three Ethiopian children with Trisomy 21 and severe COVID-19 along with a discussion of the correlation between trisomy 21 immunology and severe SARS CoV-2 infection is presented.

摘要

21三体综合征（唐氏综合征）是一种染色体疾病，除了其他全身表现外，还与体液和细胞免疫损伤有关。其发生率为每750例活产中有1例。越来越多的报告称，唐氏综合征患儿出现了严重COVID-19的症状。非洲关于儿童COVID-19和严重疾病风险分层的文献很少。本文总结了三名患有21三体综合征和严重COVID-19的埃塞俄比亚儿童的临床特征、并发症和治疗结果，并讨论了21三体综合征免疫学与严重SARS-CoV-2感染之间的相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4231/9612718/8dd4e030dfc1/fped-10-991142-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4231/9612718/2a4110cba622/fped-10-991142-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4231/9612718/8dd4e030dfc1/fped-10-991142-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4231/9612718/2a4110cba622/fped-10-991142-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4231/9612718/8dd4e030dfc1/fped-10-991142-g002.jpg

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本文引用的文献

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Enoxaparin Thromboprophylaxis in Children Hospitalized for COVID-19: A Phase 2 Trial.COVID-19 住院患儿的依诺肝素预防血栓形成：一项 2 期试验。
Pediatrics. 2022 Jul 1;150(1). doi: 10.1542/peds.2022-056726.
2
Assessment of Clinical Outcomes Among Children and Adolescents Hospitalized With COVID-19 in 6 Sub-Saharan African Countries.撒哈拉以南非洲 6 国儿童和青少年 COVID-19 住院患者临床结局评估。
JAMA Pediatr. 2022 Mar 1;176(3):e216436. doi: 10.1001/jamapediatrics.2021.6436. Epub 2022 Mar 7.
3
Risk Factors for Severe COVID-19 in Children.
儿童重症 COVID-19 的危险因素。
Pediatrics. 2022 Jan 1;149(1). doi: 10.1542/peds.2021-053418. Epub 2021 Dec 22.
4
COVID-19 in Children with Down Syndrome: Data from the Trisomy 21 Research Society Survey.唐氏综合征患儿的新冠病毒病：来自21三体研究协会调查的数据
J Clin Med. 2021 Oct 31;10(21):5125. doi: 10.3390/jcm10215125.
5
Clinical Characteristics and Histopathology of Coronavirus Disease 2019-Related Deaths in African Children.2019 年冠状病毒病相关死亡的非洲儿童的临床特征和组织病理学。
Pediatr Infect Dis J. 2021 Sep 1;40(9):e323-e332. doi: 10.1097/INF.0000000000003227.
6
Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study.利用 ISARIC WHO 临床特征协议 UK 对 COVID-19 相关院内并发症进行特征描述：一项前瞻性、多中心队列研究。
Lancet. 2021 Jul 17;398(10296):223-237. doi: 10.1016/S0140-6736(21)00799-6.
7
Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome.免疫失调与唐氏综合征成人呼吸道感染后并发症和死亡率增加的关系。
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8
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9
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